【作者】 蒙婷； 邹华红； 陈自卢； 王凯； 梁福沛；

【Author】 Ting Meng;Hua-Hong Zou;Zi-Lu Chen;Kai Wang;Fu-Pei Liang;School of Chemistry &Pharmaceutical sciences of Guangxi Normal University;College of Chemistry and Bioengineering, Guilin University of Technology;

【机构】 广西师范大学化学与药学学院； 桂林理工大学化学与生物工程学院；

【摘要】 报道了一种5,7-二氯-2-甲基-8-羟基喹啉有机金属钌配合物[Ru（η⁶-p-cymene）Cl-（MClClQ）]的合成、结构表征与抗肿瘤活性研究。MTT结果表明该配合物对4种肿瘤细胞均表现出不同程度的增殖抑制作用,总体上表现出比相应的配体强;特别是对HeLa细胞株的IC₅₀值达2.00±0.20 nM,高于相同条件下的8-羟基喹啉衍生物的有机金属钌配合物的活性,而对人体正常肝细胞HL-7702的毒性很小。实验结果表明5,7-二氯-2-甲基-8-羟基喹啉有机金属钌配合物是一种潜在的抗癌药物。更多还原

【Abstract】 Herein, we report the synthesis, structure characterization and anti-cancer of a organometallic Ru（Ⅱ）-arene complex [Ru（η⁶-p-cymene）Cl-（MClClQ）]. MTT assay showed that the complex is more selective for HeLa cell line versus normal HL-7702 cells. In addition, complex having the anti-cancer active H-MClClQ ligand showed remarkable cell cytotoxicity, giving the respective IC₅₀ values of 2.00±0.20 nM on HeLa cancer cells, which was more active than the other 8-hydroxyquinoline derivatives Ru（Ⅱ）-arene complexes. Interestingly, this Ru（Ⅱ）-arene complex was significantly less toxic to HL-7702 normal cells. The experimental results show that 5,7-dichloro-2-methyl-8-hydroxyquinoline organometallic Ru（Ⅱ） complex is a potential anticancer drug.更多还原