【作者】 林坤华； 易菊珍； 杨立群；

【Author】 Kunhua Lin;Juzhen Yi;Liqun Yang;Institute of Polymer Science, School of Chemistry, Sun Yat-Sen University;

【机构】 中山大学化学学院高分子与材料科学系；

【摘要】 <正>目前糖尿病的治疗主要依赖于每日多次皮下注射胰岛素,然而,该治疗方法将导致不能长期维持正常血糖水平,且伴随有肌肉萎缩等后遗症。针对该问题,本工作制备了负载胰岛素的普鲁兰多糖衍生物/伴刀豆蛋白水凝胶中,伴刀豆蛋白是一种植物凝集素,能与葡萄糖以非共价键的形式专一性结合,普鲁兰是一种直链微生物多糖,生物相容性和降解性较好,广泛应用于生物医药等领域。更多还原

【Abstract】 Nowadays, clinical treatment of diabetes mellitus mostly depends on multiple daily hypodermic injections of insulin, which can’t maintain the long-term stabilization of the regular plasma glucose level, it also results in some sequelae like myophagism. To solve this problem, pullulan with favorable biocompatibility and degradability was used to react with Concanavalin A(ConA) with specific saccharide-binding property in this work. First, pullulan derivative with carboxyl group(CPUL) was synthesized and characterized by 1 H NMR and FTIR techniques. Then,CPUL-ConA hydrogel was prepared through crosslinking method and further loaded with insulin. Some techniques including FTIR, SEM, and UV-vis were used to study the structure, morphology, and drug-release behavior of CPUL-ConA hydrogel. The viscoelasticity of CPUL-ConA and Insulin/CPUL-ConA hydrogels was studied by rheology[1] and the results were shown in Figure 1. The results showed that the hydrogels had formed a relatively stable network structure(Figure 1 a), and the addition of insulin might affect the network structure of the CPUL-ConA hydrogel(Figure 1 b).更多还原