【作者】 李菲； 高杰； 何锡文； 陈朗星； 张玉奎；

【Author】 Li Fei;Gao Jie;He Xiwen;Chen Langxing;Zhang Yukui;College of Chemistry, University of Nankai;Dalian Institute of Chemical Physics, Chinese Academy of Sciences;

【机构】 南开大学化学学院； 中国科学院大连化学物理研究所；

【摘要】 马兜铃酸(Aristolochic acids,简称AAs)也被称为马兜铃总酸、增噬力酸或木通甲素,是一类硝基菲羧酸。2017年10月27日,在世界卫生组织国际癌症研究机构公布的致癌物清单中,马兜铃酸、含马兜铃酸的植物在一类致癌物清单中。本文以马兜铃酸为模板分子,磁性碳纳米管为载体,苯基三甲氧基硅烷(PTMOS)为功能单体,正硅酸乙酯(TEOS)为交联剂,利用简单的溶胶-凝胶[1]方法制备了对马兜铃酸有特异选择性的表面分子印迹聚合物。采用高效液相色谱(HPLC)测定分子印迹[2]聚合物材料的吸附性能。研究表明,所得分子印迹聚合物材料对马兜铃酸有很好的特异性识别,吸附速度快,最大饱和吸附量为31.17 mg/g。同时采用红外技术(FT-IR)、扫描电镜(SEM)等对聚合物的化学结构、形态和尺寸等进行了表征。更多还原

【Abstract】 In this study, magnetic molecularly imprinted polymers（MIP@MCNTs-Fe₃O₄） as the selective sorbents for separation of aristolochic acid（AAs） were prepared by a facile sol-gel routes, with aristolochic acid as the template molecule, PTMOS as the functional monomer, TEOS as the cross-linker. High-performance liquid chromatography（HPLC） was used to investigate the adsorption and recognition properties of the MIPs. The obtained polymers exhibited high thermostability, fast equilibrium time, and excellent binding ability. The synthesized MIPs were characterized by Fourier-transfer infrared spectroscopy, scanning electron microscopy and so on. The maximum adsorption of AAs by the polymers was about 31.17 mg/g. This work provided a promising and facile method for selectively enrichment and purification of aristolochic acid from complex herbal medicines.更多还原