【作者】 陈千山； 史雯慧； 吴朝阳； 俞汝勤；

【Author】 Qianshan Chen;Wenhui Shi;Zhaoyang Wu;Ruqin Yu;College of Chemistry and Chemical Engineering, Hunan University;

【机构】 湖南大学化学化工学院化学生物传感与计量学国家重点实验室；

【摘要】 将分子印迹聚合物的特性引入到光子晶体阵列中,可制备分子印迹光子晶体水凝胶(MIPHs)。当水凝胶特异性识别目标分子后,内部的纳米空腔被填充,光子晶体的晶格参数发生改变,衍射波长随之移动,当衍射波长处于可见光范围内时,可直接裸眼观察到颜色的变化。MIPHs兼具分子印迹与光子晶体的特性,有望应用于环境中待测分子的快速、灵敏及特异性检测。本课题组制备了一种以L-组氨酸为目标分子的MIPHs传感器,其在结合了目标分子后,水凝胶的体积膨胀且平均有效折射率增大,使衍射波长红移。该传感器具有较高的灵敏度(可检测至10 pM)、良好的选择性和稳定性,且响应时间短(在几分钟内即可达到反应平衡)。此传感器操作简单、成本低廉,有望发展成为一种便携式的实时检测工具。更多还原

【Abstract】 The molecularly imprinted photonic hydrogels sensors, which combined combing the MIPs and the photonic crystals, can offer both the special selectivity of MIPs and the native responsiveness of the PC, and it is expected to become a prosperous sensing method. Our group has developed a MIPHs sensor for label-free detection of L-Histidine. The inverse opal structure of MIPHs have abundant binding sites which can reversibly combine with L-His through hydrogen bonding, making the sensor can rapidly, specificity and sensitivity respond to L-His. In addition, the Bragg diffraction peak of MIPHs will red-shift after absorbing L-His and produce a readable optical signals without other chemical modification. MIPHs are the optimization and improvement of photonic crystal which will provide a wide application prospect for detection of low concentration material.更多还原