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构筑多功能¹⁹F磁共振纳米探针用于肿瘤多模态成像及光热治疗

Fabrication of Multifunctional ¹⁹F MRI Nanoprobes for Multimodal Imaging and Photothermal Therapy

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【Author】 Gaofei Hu;Chang Guo;Juan Tang;Suying Xu;Leyu Wang;State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology;

【机构】北京化工大学化工资源有效利用国家重点实验室；

【摘要】 ¹⁹F核天然丰度100%,化学位移范围宽且无内源性背景干扰,因此¹⁹F磁共振成像(¹⁹F MRI)技术对于病理成像具有更高的灵敏度和分辨率,为发展为生物医学领域尤其是深度组织成像方面提供了新的机遇^[1],基于含氟有机配体与生物相容性两亲聚合物自组装包覆功能性有机分子或无机纳米颗粒构筑多功能复合纳米探针可实现优势互补多模态成像以及癌症治疗的功能一体化,在研究新型诊疗方法中显现巨大的应用前景^[2,3]。本文通过油胺修饰的两亲聚合物(PSI_OAm)与不同含氟配体,以及聚集发光的有机分子或Cu7S4纳米颗粒组装,进而构筑核壳结构纳米探针,可实现高效19F MRI和荧光双模态成像,以及19F MRI与光热治疗。更多还原

【Abstract】 ¹⁹F MRI has higher intensity and resolution for tumor imaging due to a broad range of chemical shifts and almost no endogenous background of ¹⁹F,and gained increasing attention in bio-imaging.Biocompatible and amphiphilic polymer (PSI_OAm) is able to be assembled with functional fluorine ligands and organic molecules （ETTA） with AIE property or Cu₇S₄ nanoparticles with high photothermal conversion efficiency.Thus,two multifunctional core-shell nanoprobes were successfully fabricated of which ETTA@PSI_OAm-PDTES displayed excellent FI-¹⁹F MRI dual-modal imaging,and Cu₇S₄@PSI-¹⁹F could be applied for simultaneous ¹⁹F-MRI and PTT in vivo.更多还原