节点文献
A novel IFNα-induced long noncoding RNA negatively regulates immunosuppression by interrupting H3K27 acetylation in head and neck squamous cell carcinoma
【机构】 上海第九人民医院; 上海交通大学医学院附属第九人民医院;
【摘要】 <正>Purpose/Background:Interferon alpha(IFNα) is a well-established regulator of immunosuppression in head and neck squamous cell carcinoma(HNSCC), while the role of long noncoding RNAs(lncRNAs) in immunosuppression remains largely unknown. Materials and Methods:Differentially expressed lnc RNAs were screened under IFNα stimulation using lnc RNA sequencing. The role and mechanism of lncRNA in immunosuppression were investigated in HNSCC in vitro and in vivo.
【Key words】 Interferon alpha;
lncMX1–215;
Immunosuppression;
H3K27 acetylation;
HNSCC;
- 【会议录名称】 2020年全国口腔颌面-头颈肿瘤学术大会暨中华口腔医学会口腔颌面-头颈肿瘤专业委员会学术年会——创新超越、共赢未来论文汇编
- 【会议名称】2020年全国口腔颌面-头颈肿瘤学术大会暨中华口腔医学会口腔颌面-头颈肿瘤专业委员会学术年会——创新超越、共赢未来
- 【会议时间】2020-11-11
- 【会议地点】中国湖北武汉
- 【分类号】R739.91
- 【主办单位】中华口腔医学会口腔颌面-头颈肿瘤专业委员会