环形RNA hsa＿circ＿0007059通过AKT/mTOR通路影响口腔鳞状细胞癌的发展(英文)

【作者】 沈月洪； 杨宏宇；

【机构】 北京大学深圳医院；

【摘要】 <正>Purpose/Background:Oral squamous cell carcinoma（OSCC）, the most common oral cancer, damages oral epithelial cells after the accumulation of multiple genetic mutations. Although emerging evidence supports the key role of circular RNAs（circRNAs） in various malignancies, the clinical value and function of circRNAs in OSCC remain unclear. Materials and Methods:In this study, patients with OSCC（n = 8） and controls（n = 8） were compared using high-throughput sequencing and microarray circRNA expression profiles. Hsa_circ₀007059 levels in OSCC tissues and cell lines were assessed by quantitative reverse-transcription chain reaction. Loss-offunction and gain-of-function experiments were performed to determine whether hsa_circ₀007059 affects malignant behavior in SCC15 and CAL27 cells.更多还原