枸杞多糖和黄芪多糖对阿尔茨海默病的影响

【作者】 王亚盟； 刘利娥；

【机构】 郑州大学公共卫生学院；

【摘要】 阿尔茨海默病(Alzheimer’s disease,AD)是一种神经退行性疾病,呈进行性发展趋势,严重影响患者的生活质量,随着人口老龄化进程的不断加剧,AD患者人数快速增加,而其发病原因、发病机制十分复杂,至今尚不明确。目前临床上治疗AD主要以西药为主,但具有毒性大、易耐药等局限性,因此越来越多的研究重点转移到中草药等具有毒副作用小、可长期服用等众多优点的天然产物上。研究发现,植物多糖具有改善学习记忆能力、抗氧化应激、抗自由基损伤、抗炎症和抑制神经细胞凋亡等多方面的作用,可以多靶点预防和治疗AD的发生、发展。本文详细综述了枸杞多糖、黄芪多糖与AD发生发展过程中β淀粉样蛋白(Aβ)和同型半胱氨酸(Hcy)有关的研究进展,为它们进一步的相关开发利用提供系统的证据。更多还原

【Abstract】 Alzheimer’s disease(AD) is a neurodegenerative disease with a progressive development trend,which seriously affecits the quality of patients ’ life.With the aging of population,the number of AD patients continues to increase quickly.The etiology and pathogenesis are very complicated,which are still unclear.At present,the clinical treatment of AD is mainly based on western medicine,but it has many limitations such as high toxicity and easy resistance.Therefore,more and more researches focus on natural products such as Chinese medicines with small side effects and can be used for long term.Several studies have found that plant polysaccharides have various effects on improving learning and memory ability,anti-oxidative stress,anti-free radical damage,anti-inflammation and inhibiting nerve cell apoptosis,making it possible to treat and control AD from the perspective of multiple targets.This article reviews in detail the research progress of Lycium barbarum polysaccharides and Astragalus polysaccharides related to β-amyloid(Aβ) and homocysteine(Hcy)in the occurrence and development of AD,and provides systematic,evidence for the further development and utilization of these two Chinese herbal polysaccharides.更多还原