【作者】 董洁； 宋国胜； 梁庆优；

【Author】 DONG Jie;SONG Guo-sheng;LIANG Qing-you;Department of Radiation Oncology,The Third Affiliated Hospital of Sun Yat-sen University;Analytical and Testing Center,South China University of Technology;

【机构】 中山大学附属第三医院肿瘤放疗科； 华南理工大学分析测试中心；

【摘要】 在世界范围内癌症是人类健康的主要威胁,放射治疗(放疗)是癌症治疗的主要方法之一,放疗的精准程度极为重要。体膜用来在放疗中对病人进行固定,其主要成分为交联的聚己内酯。杨氏模量对体膜的尺寸稳定性非常关键,快速、准确表征杨氏模量有着非常重要的意义。建立了拉曼光谱中碳碳键反称伸缩的峰面积和对称伸缩的峰面积之比与交联聚己内酯杨氏模量的关系。杨氏模量由原子力显微镜测定,拉曼光谱和原子力显微镜扫描同一个微区范围,从而在理论上提高了实验的准确度。结果表明,在实际使用范围内杨氏模量和峰面积之比呈线性关系,因此拉曼光谱可用于体膜杨氏模量的测定,具有重要的实用价值。更多还原

【Abstract】 Cancer is now the main threat to human health in the world.Radiotherapy is one of the major modalities to treat cancer,where precision is of extreme importance.Immobilization membrane,whose main component is cross-linked polycaprolactone(PCL),is employed for positioning the patients in the treatment.The Young’s modulus is the key factor to maintain the shape of this material,so rapid,convenient and accurate characterization of the Young’s modulus is very important.This work established the relationship between the Young’s modulus and the area ratio of the symmetric peak to the asymmetric ones in C—C stretching vibration region.The Young’s modulus was determined by atomic force microscopy(AFM) that scanned the same micro area as Raman spectrometer did.The design of concordant area improves experimental accuracy theoretically.The regression curve shows that the Young’s modulus linearly increases with the ratio defined above,which,consequently,shows that Raman is suitable for determining the Young’s modulus of cross-linked PCL and can be used in practice.更多还原