【作者】 杨志新； 崔陶陶； 龙泽凡； 崔亚颖； 李姣莹； 王玉满；

【Author】 Yang Zhixin;CuiTaotao;Long Zefan;Cui Yaying;Li Jiaoying;Wang Yuman;College of TCM,Chengde Medical University;Heilongjiang,university of TCM;Hebei key laboratory of traditional Chinese medicine research and development,Institute of Traditional Chinese Medicine of Chengde Medical University;

【机构】 承德医学院中医学院； 黑龙江中医药大学； 河北省中药研究与开发重点实验室承德医学院中药研究所；

【摘要】 目的:探讨"相对穴"对类风湿性关节炎的艾灸效应及作用机制。方法:32只Wistar大鼠随机分为:正常组(K组)、模型组(M组)、"相对穴"阳陵泉与阴陵泉组(AB组),肾俞、足三里组(CD组);每组8只。艾灸均取双侧穴,隔日灸,选用精制艾绒2mg/壮,每穴5壮,施灸10次。于造模前后及干预结束后,测量各组大鼠左足底热痛阈值;干预结束后拍摄大鼠左足爪X线,检测足部患处MC数量及脱颗粒。结果:模型组大鼠热痛阈值较K组均下降(P<0.05),足部患处MC数量及脱颗粒均增加;艾灸干预后,AB、CD组热痛阈值较M组均升高(P<0.05);MC数量及脱颗粒较M组均减少,减少程度AB组优于CD组;足、爪影像资料显示,AB、CD组足、爪软组织肿胀、骨关节畸形、骨质破坏较M组减轻,减轻程度AB组优于CD组。结论:艾灸"相对穴"有效干预RA,其机制可能与MC数量脱颗粒密切相关。更多还原

【Abstract】 Objective: To explore the moxibustion effect and mechanism of "the Complementary Acupoints" on rheumatoid arthritis. Methods: 32 Wistar rats were randomly divided into 4 group : blank control(K) 、 model group(M group), "the Complementary Acupoints" Yanglingquan and Yinlingquan group(AB group), Shenshu, Zusanli group(CD group), 8 in each group. Moxibustion takes both sides, every other day moxibustion, choose refined cashmere 2 mg per wick, 5 strong each hole, 10 times moxibustion. Before and after the modeling and after the intervention, the left foot sole thermal pain threshold of each group was measured. After the intervention, the left foot paw X-ray was taken to detect the number of MC in the foot and degranulation. Results: The thermal pain threshold of the model group was lowerthan that of the K group(P<0.05). The number of MC in the affected area and the degranulation were increased. After the moxibustion intervention, the thermal pain threshold of the AB and CD groups was higher than that of the M group.(P<0.05); MC number and degranulation were decreased compared with M group, and the degree of reduction was better than that of CD group.The data of foot and claw showed that the foot and paw soft tissue swelling, bone and joint deformity and bone destruction were better in AB and CD groups. Group M was relieved, and the degree of reduction was better in the AB group than in the CD group. Conclusion: The "the Complementary Acupoints" of moxibustion can effectively intervene in RA, and its mechanism may be closely related to the number of MC degranulation.更多还原