【作者】 孙雯； 曾巧钱； 杜慧； 汪永红； 俞建； 时毓民； 李素环；

【Author】 SUN Wen;ZENG Qiao-qian;DU Hu;WANG Yong-hong;YU Jian;SHI Yu-min;LI Su-huan;Traditional Chinese Medicine Department,Children’s Hospital of Fudan University;Department of Respiratory Wuhan Children’s Hospital,Tongji Medical College,Huazhong University of Science and Technology;Department of Pediatrics,Yantaishan Hospital;

【机构】 复旦大学附属儿科医院中医科； 华中科技大学同济医学院附属武汉市儿童医院； 山东省烟台市烟台山医院；

【摘要】 目的通过临床观察哮喘患儿C-ACT评分及肺功能的变化,明确中药分期论治方案治疗儿童哮喘的临床疗效,并与西药组进行比较。方法采用随机数字表法,将162例哮喘患儿随机分为中药组84例和西药组78例。中药组以中药分期分证论治方案治疗,西药组以常规的西药(沙丁胺醇、孟鲁司特)治疗,疗程为12周。比较治疗前后两组患儿的C-ACT评分、哮喘控制率、肺功能的变化。结果中药组C-ACT评分从治疗后4W开始上升,治疗后12W为22.88±1.69分,与西药组比较有明显差异(P<0.01);哮喘控制率高于西药组(92.67%vs.81.33%,P’=0.03);中药组治疗后的肺通气功能指标(FEV1%、FEVl/VCmax、FVC)与治疗前比较均有明显改善(P=0.01,0.03,0.00),中药组有55.56%患儿肺功能恢复正常,优于西药组(32.00%),P=0.01。结论:中药分期论治方案能有效控制哮喘发作,优于沙丁胺醇和孟鲁司特治疗组,能改善患儿肺功能。更多还原

【Abstract】 Objective:To clarity the clinical effect of TCM staging treatment for Pediatric Asthma by observe the changes of C-ACT scores and pulmonary function after treatments,and compare with the SM(salbutamol and montelukast) group.Methods:A total of 182 children with asthma were randomized into the TCM group(n=84) or SM group(n=78).Patients in the TCM group were treated with a series of TCM prescriptions,whereas those in the SM group received salbutamol and montelukast;both groups received their respective treatment for 12 weeks.The asthma control rate and changes of pulmonary function after treatment were compared between the two groups.Results:The C-ACT scores of the TCM group was increased after 4 W,it was 22.88±1.69 after 12 W treatment.there was significant differences between TCM group and SM group(P<0.01) The asthma control rate of the TCM group was higher than that in the SM group(92.67%vs.81.33%,respectively,P’=0.03) The indexes of pulmonary ventilation function(FEV1%,FEV1/VCmax,FVC) in TCM group significantly improved after treatment(P=0.01,0.03,0.00,respectively);In the TCM group,55.56% of the children had normal pulmonary function,which was better than the SM group(32.00%),P=0.01.Conclusion:The Traditional Chinese Medicine staging treatment performs better in controlling pediatric asthma compared with that of salbutamol and montelukast,It can improve the pulmonary function.更多还原