【作者】 杨春松； 张伶俐； 俞丹； 王艳梅； 许群芬；

【Author】 YANG Chun-song;ZHANG Ling-Li;YUdan;WANG Yan-mei;XuQun-fen;Department of Pharmacy,Evidence-based Pharmacy Center,West China second hospital;Key Laboratory ofBirth Defects and Related Diseases of Women and Children,Sichuan University;Department of Pediatrics,West China second hospital,West China second hospital;

【机构】 四川大学出生缺陷与相关妇儿疾病教育部重点实验室； 四川大学华西第二医院药学部/循证药学中心； 四川大学华西第二医院儿科；

【摘要】 目的:探讨孕期危险因素与儿童抽动障碍(TDs)的关系,为预防抽动障碍的发生提供循证医学证据。方法:采用1:1匹配的病例对照研究方法,对华西第二医院儿童神经内科150例新确诊的TDs患者和150例未患病的儿童保健对象进行问卷调查。采用单因素及多因素非条件Logistic回归分析导致TDs患病的相关孕期危险因素。结果:病例组中150例新发TDs患儿,男性110例,年龄9.18±2.60。对照组中150例儿童保健对象,男性109例,年龄9.09±2.52。单因素研究结果显示:怀孕年龄、妊娠反应程度、分娩并发症、围生期缺氧窒息、被动吸烟、怀孕期间受精神刺激和胎龄是TDs发病的危险因素(P<0.05)。多因素非条件Logistic回归模型分析结果显示,怀孕年龄、分娩并发症、被动吸烟、怀孕受精神刺激是TDs发病的危险因素。结论:怀孕年龄、分娩并发症、被动吸烟、怀孕受精神刺激等孕期危险因素可能与TDs发病有关联,应通过开展健康教育等方式进行干预,积极倡导孕期避开相关暴露因素,以预防TDs的发生。更多还原

【Abstract】 Objective:To explore the relationships between prenatal risk factors and tic disorders(TDs), and provide a scientific basis for the prevention of TDs Method: In the 1:1 matched case control study,150 children with TDs from west china second hospital and 150 healthy individuals were enrolled,and were investigated used a questionnaire to collect information of prenatal risk factors. Univariate and multivariate logistic regression were used to assess the effects of each related factor on TDs risk.Result: In the case group, 150 newly diagnosed patients with TDs were included,110 were male, and the age was 9.18±2.60. In the control group, 109 cases were men, and the age was 9.09±2.52.Univariate logistic regression showed that pregnant age, pregnancy reaction, birth complications, perinatal asphyxia, passive smoking during pregnancy, the mental stimulation and gestational age were the risk factors for TDs(P<0.05). Multivariate logistic regression showed that the risk factors of TDs were pregnancy age, delivery complications, passive smoking, pregnancy and mental stimulation.Conclusion: Pregnancy age, delivery complications, passive smoking, pregnancy and mental stimulation may be associated with TDs. Health education for the disease should be strengthened and avoiding prenatal risk factors should beadvocated to prevent TDs.更多还原