【作者】 王兰； 阳勇； 王静； 唐丽瓯； 柳希芹； 孙妍萍；

【Author】 WANG lan;YU xiaofeng;WANG jing;TANG Li’ou;LIU xiqin;SUN yanping;Department of medicine,Qingdao University;the Eighth People’s Hospital of Qingdao;Affiliated Hospital of Qingdao University;

【机构】 山东省青岛市青岛大学医学部； 山东省青岛市第八人民医院； 山东省青岛市青岛大学附属医院；

【摘要】 <正>目的探讨不同类型癫痫及抗癫痫药物(Anti-epileptic drugs,AEDs)对患者大脑皮层兴奋性差异的影响。方法受试者分为局灶未服药组(n=14)、局灶服药组(n=17)、全面未服药组(n=13)、全面服药组(n=8)及正常对照组(n=15)5组。利用经颅磁刺激技术测量受试者静息运动阈值、运动诱发电位波幅及潜伏期并对测量值进行统计比较。结果各组间静息运动阈值的比较中,更多还原

【Abstract】 Objective:To explore the effect of different types of epilepsy and anti-epileptic drugs(AEDs) on the excitability difference of cerebral cortex in patients Methods The subjects were divided into five groups:focal epilepsy without medication(n=14),focal epilepsy with medication(n=17),general epilepsy without medication(n=13),general epilepsy with medication(n=8)and normal group(n=15).The subjects who met the standard were selected to measure the resting motor threshold,the amplitude and latency of motor evoked potential by transcranial magnetic stimulation,and the measured values were compared statistically.Results In the comparison of resting motor thresholds among groups,there were statistically significant differences between the focal epilepsy without medication and the group of focal epilepsy with medication,between the focal epilepsy without medication and the general epilepsy with medication.The significant differences in the amplitude of motor evoked potential among groups were found in the comparison of the focal epilepsy without medication and the normal control group respectively.The same difference lies in the group of focal epilepsy with medication and the normal control group respectively.No significant results were found in other comparisons(P>0.05).Conclusion The cortical excitability of patients with focal epilepsy is significantly higher than that of normal people,and antiepileptic drugs can significantly inhibit the cortical excitability level of patients with focal epilepsy.更多还原