【作者】 焦剑； 张立； 释栋； 路瑞芳； 孟焕新；

【机构】 北京大学口腔医院牙周科；

【摘要】 目的:旨在分析多因素综合作用下广泛型侵袭性牙周炎患者牙周非手术治疗的疗效及其影响因素。方法:从北京大学口腔医院信息中心提取2007年1月至2015年1月所有患者的牙周检查资料,选取(1)完成牙周非手术治疗且至少有一次复查记录、(2)全身健康、(3)未曾接受牙周手术治疗、(4)随访时间大于6周、(5)诊断为广泛型侵袭性牙周炎的患者资料,分析牙周非手术治疗前后探诊深度(PD)和Mazza出血指数(BI)的变化情况,建立多水平线性回归方程(因变量为PD降低值)和多水平logistic回归方程(因变量为BI是否降低),评价非手术治疗的疗效及其影响因素。结果:本研究共纳入患者1 089名。经过牙周非手术治疗,广泛型侵袭性牙周炎患者平均PD由治疗前的4.53mm降至3.27mm;PD≥5mm位点百分比由47.37%降至16.95%;BI>1牙齿百分比93.22%降至75.84%;BI>2牙齿百分比由77.85%降至34.61%;以上数值的降低均有统计学意义。多水平多因素回归模型显示:广泛型侵袭性牙周炎患者,PD降低值与维护频率、性别、辅助全身应用抗菌药物、基线松动度、牙齿类型、基线PD显著相关,BI是否降低与维护频率、辅助全身应用抗菌药物、基线附着丧失、基线牙齿松动度、牙齿类型、基线PD显著相关。结论:本研究证明非手术治疗对于广泛型侵袭性牙周炎患者一种有效的治疗方式,广泛型侵袭性牙周炎患者牙周非手术治疗的疗效主要受基线PD、牙齿类型、患者依从性、辅助全身应用抗菌药物和基线松动度的影响。更多还原

【Abstract】 AIM:To test the effectiveness of NSPT and its influential factors on generalized aggressive periodontitis.METHODS:Patient electronic periodontal examination charting records had been collected.Data of target population,patients who had finished NSPT and had at least one recall records and were systemically healthy,with no periodontal surgical history,a follow-up at least 6 weeks and diagnosed as generalized aggressive periodontitis,were extracted.Changes of probing depth(PD) and Mazza bleeding index(BI) on baseline and the last re-call were analyzed.Multi-level linear regression(PD reduction was the dependent variable) and multi-level logistic regression(whether BI reduced or not was the dependent variable) were used to analyze the influential factors of NSPT.RESULTS:In the present study 1,089 patients with generalized aggressive periodontitis were enrolled.Mean PD reduced from 4.53 mm to 3.27 mm,mean percentage of sites with PD≥5 mm reduced from 47.37% to 16.95%,mean percentage of teeth with BI>1 reduced from 93.22% to 75.84% and mean percentage of teeth with BI>1 reduced form 77.85% to 34.61%.Multi-level regression models showed that FPM,gender,adjunctive systemic use of antibiotics,baseline mobility,tooth type and baseline were significantly associated with PD reduction and FPM,adjunctive systemic use of antibiotics,baseline mobility,baseline AL,tooth type,baseline PD were significantly associated with BI reduction.CONCLUSION:NSPT is effective for Chinese patients with generalized aggressive periodontitis patients.The effectiveness of NSPT is mainly influenced by baseline PD,tooth type,PFM and adjunctive systemic use of antibiotics and baseline mobility.更多还原