【作者】 冯淑梅； 何健； 格鹏飞； 吴珊； 张宏茂； 何炯；

【Author】 Fengshumei;Hejian;Gepengfei;Wushan;Zhanghongmao;Hejiong;

【机构】 甘肃省疾病预防控制中心； 甘肃省两当疗养院；

【摘要】 目的探讨甘肃省影响麻风病人2级畸残的相关因素,为麻风病的早期发现,降低2级畸残提供科学依据。方法通过"全国麻风病防治管理信息系统"(LEPMIS)收集2000年1月至2018年12月确诊的麻风病人129例,根据是否有2级畸残将其分为两组:2级畸残组37例,非2级畸残组92例。观察影响2级畸残的相关因素。结果麻风病人诊断延迟期和2级畸残比呈明显的正相关(r=0.70,P<0.05),诊断延迟期越长,发生2级畸残的风险越高。将诊断延迟期进行分类后,对相关因素进行多因素Logstic回归,结果显示确诊年龄和患者诊断延迟期为影响2级畸残的主要因素,和≤30岁的患者进行比较,确诊年龄≥60岁发生2级畸残的风险达到5.98倍。和患者诊断延迟期<6个月的进行比较,≥6个月的发生2级畸残的风险达到6.64倍。结论患者诊断延迟期不超过6个月可以作为麻风病人早期发现的标志,患者从首次出现症状的前6个月主动就医、及时就诊可以有效降低2级畸残的发生。更多还原

【Abstract】 Objective To explore the influence factors of grade 2 disability of leprosy patients in Gansu Province,so as to provide a scientifice basic for early detection and reduction of grade 2 disability.Method129 cases of leprosy diagnosed between January 2000 and December 2018 were collected through the Leprosy Management Information System in China(LEPMIS).Whether there were grade 2 disability(G2 D)to divid into two groups,37 cases in grade 2 disability and 92 cases in none.To observe the influence factors affecting grade 2 disability.Results There was a significant positive correlation between delayed diagnosis and grade 2 disability(r=0.70,P<0.05).The longer the delay in diagnosis,the higher the risk of grade 2 teratodisability.After classifed the delay of diagnosis,Logstic regression was used to analyze the related factors.The results showed that age of diagnosis and delay of diagnosis of patients were the major factors.Among them,the age of diagnosis was over 60 years,the odds of G2 D were 4.20 times higher compared to when the age of diagnosis was under 30 years.When the patients with delay of diagnosis was more than 6 months,the odds of G2 D were 6.64 timeshigher compared to when the patients with delay of diagnosis was less than 6 months.Conclusion The patients with delay of diagnosis was less than 6 monthscan be used as a marker for early detection.Patients who take the initiative to seek medical treatment timely from the first 6 months of symptom onset can effectively reduce the occurrence of G2 D.更多还原