【作者】 宋世平；

【Author】 Shiping Song;Shanghai Institute of Applied Physics,Chinese Academy of Sciences;

【机构】 中国科学院上海应用物理研究所；

【摘要】 建立了一种基于自研制多通道电化学传感系统和多通道生物传感电极阵列的表观遗传学分析平台,结合DNA纳米技术,开展了一系列基于基因甲基化修饰和羟甲基化修饰的分析检测。应用该方法,通过对特定疾病相关的甲基化修饰标志序列分析,建立了效果显著且性能可靠的检测技术。更多还原

【Abstract】 Electrochemical biosensors are widely studied and applied in cancer related biomarker prognostic,medical health screening,environmental quality monitoring,and some other related areas due to its rapid speed,high sensitivity,and low cost.Here we focused on nano-probe based electrochemical sensor design and developed several sensitive electrochemical methods for 5-mC and 5-hmC detection,as well as their application forclinical sample detection.更多还原