【作者】 刘炯烨； 洪海龙； 靳添添； 竺宁； 韩利民；

【Author】 Liu Jiong-ye;Hong Hai-long;Jin Tian-tian;Zhu Ning;Han Li-min;College of Chemical Engineering, Inner Mongolia University of Technology;

【机构】 内蒙古工业大学化工学院；

【摘要】 采用超临界流体强制分散溶液(SEDS)技术制备药物的超细微粒是近几年研究较多的课题,SEDS技术不仅可以制备无溶剂残留的超细微粒,还可以提亲脂类药物的溶出度和生物利用度。本文选用姜黄素粉末为原料,通过分离纯化得到纯度较高的姜黄素晶体,利用SEDS法探索了溶剂种类和压力对超细化微粒的影响。通过扫描电子显微镜(SEM)和粒径分布计算软件,对姜黄素的粒径和形貌进行了测定。最后,通过SEDS方法在丙酮和二氯甲烷的混合溶剂中,压力为8 MPa下成功制备了树枝状和棒状的超细微粒,最小粒径为2.46μm。更多还原

【Abstract】 The use of Solution Enhanced Dispersion by Supercritical Fluids(SEDS)technology to prepare ultrafine particles of drugs has been a subject of research in recent years.SEDS technology can not only prepare ultrafine particles without solvent residue,but also improve the dissolution and bioavailability of lipophilic drugs.In this paper,curcumin powder was used as raw material to obtain higher purity curcumin crystals by separation and purification.The effects of solvent type and pressure on ultrafine particles were explored by SEDS method.Scanning electron microscopy(SEM)and The particle size distribution calculation software was used to determine the particle size and morphology of curcumin.Finally,dendritic and rod-shaped ultrafine particles were successfully prepared by a SEDS method in a mixed solvent of acetone and dichloromethane at a pressure of 8 MPa,with a minimum particle size of 2.46μm.更多还原