【作者】 陈标奇； 项舒婷； 王士斌； 陈爱政；

【Author】 Chen Biao-qi;Xiang Shu-ting;Wang Shi-bin;Chen Ai-zheng;College of Chemical Engineering, Huaqiao University;Fujian Provincial Key Laboratory of Biochemical Technology (Huaqiao University);

【机构】 华侨大学化工学院； 福建省生物化工技术重点实验室(华侨大学)；

【摘要】 我们采用超临界流体(SCF)技术设计了一种稳定性和生物相容性良好,具有pH和近红外光响应性的丝素蛋白(SF)包封的吲哚菁绿(ICG)纳米颗粒。该纳米颗粒在肿瘤酸性环境下能加速ICG的释放,并在808 nm近红外(NIR)光照射下能显著增强光热治疗效率。体内外实验表明,ICG-SF纳米颗粒具有优异的生物安全性,仅在光致高温下抑制肿瘤细胞的生长。总之,这些结果表明,通过SCF工艺制备的ICG-SF纳米颗粒具有更高的PTT效率,在肿瘤诊断和光热治疗中有较好的应用前景。更多还原

【Abstract】 We designed a stable,biocompatible,and dual-triggered formulation of indocyanine green(ICG)-encapsulated silk fibroin(SF)(ICG-SF)nanoparticles using the supercritical fluid(SCF)technology.We demonstrated that the pH-responsive release of ICG from SF specifically in the tumor acidic environment and its substantial activation with near-infrared(NIR)light at 808 nm significantly enhanced the PTT efficiency through hyperthermia.Moreover,ICG encapsulation in the SF through this eco-friendly approach has offered excellent photothermal stability.In vitro and in vivo photothennal experiments have shown that these ICG-SF nanoparticles were capable of devastating tumor cells merely under light-induced hyperthermia.Together,these results have suggested that the biocompatible ICG-SF nanoparticles prepared by the SCF process resulted in high PTT efficiency,and may have a great potential as a delivery system for sustained cancer therapy.更多还原