【作者】 张晓； 徐晓勇； 邵旭升； 李忠；

【Author】 Xiao Zhang;Xiaoyong Xu;Xusheng Shao;Zhong Li;Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology;Shanghai Collaborative Innovation Center for Biomanufacturing Technology;

【机构】 上海市化学生物学重点实验室华东理工大学药学院； 上海制造技术合作创新中心；

【摘要】 由于新烟碱类杀虫剂的抗性问题日益严重以及其对鳞翅目害虫的低活性,因此亟需一类"超级新烟碱"来解决问题。固定硝基为顺式构型为新烟碱杀虫剂的分子设计提供了一种新的方法。杂环或大基团的引入是固定硝基顺式构型的两种设计思路。基于此设计思路我们设计合成了一系列新烟碱类似物。同时,也发现了一类新烟碱类杀虫剂的新颖增效剂。本论文主要介绍了本课题组近年来基于中间体6-Cl-PMNI所进行的相关研究工作。更多还原

【Abstract】 Resistance development and limited lepidopteran activities call for the discovery of"super-neonicotinoids"solving these problems.Fixing the nitro group in the cis-configuration provided a new approach for neonicotinoid molecular design.Introductions of the heterocycle or a bulky group are two synthesis concepts to fix the cis-configuration of the nitro group.On the basis of the tactic,a series of neonicotinoids analogues were designed and synthesized.And,we found a novel insecticide synergist for insecticidal neonicotinoids.This paper mainly introduced the related research of our group based on the intermediate 6-Cl-PMNI.更多还原