【作者】 关爱莹； 赵宇； 王卫伟； 刘鑫磊； 王明安；

【Author】 Aiying Guan;Yu Zhao;Weiwei Wang;Xinlei Liu;Mingan Wang;Department of Applied Chemistry, College of Sciences, China Agricultural University;

【机构】 中国农业大学理学院应用化学系；

【摘要】 将多样性导向合成策略应用于3-乙酰基-4-苯基-5,5-螺环己基丁烯内酯的羰基进行多样化衍生,合成了一系列结构新颖的3-乙酰基-4-苯基-5,5-螺环己基丁烯内酯衍生物,它们的化学结构经¹H NMR、¹³C NMR和高分辨质谱的确证.活体及离体生物活性测试结果表明,一些化合物对植物病原菌显示出优异的杀菌活性,如化合物7在400μg/mL浓度下对黄瓜霜霉病和玉米锈病的防效均为100%.更多还原

【Abstract】 The diversity-orientied synthesis strategy was utilized to diversely derive from the carbonyl of 3-acetyl-4-phenyl-5,5-spirocyclohexylbutenolide,a series of novel 3-acetyl-4-phenyl-5,5-spirocyclohexylbutenolide derivatives were synthesized.Their structures were elucidated by ¹ H NMR,¹³C NMR,and HR-MS data.The preliminary in vivo and vitro bioassay results showed that some of them exhibited excellent fungicidal activity against phytopathagens,such as 7 showed both 100% control effect against Pseudoperonospora cubensis and Puccinia polysora at the concentration of 400 μg/mL.更多还原