Issues in the Development of New Drug Delivery System with Patent Medicine as the Aim

【作者】 李国锋； Qianying Liang； Boxin Zhao； Jianhai Chen；

【Author】 Guofeng Li;Qianying Liang;Boxin Zhao;Jianhai Chen;Rational Medication Evaluation and Drug Delivery Technology Lab, Nanfang Hospital, Southern Medical University;

【机构】 南方医科大学南方医院药学部； 南方医科大学合理用药评价与药物递送发展实验室； 南方医科大学药学院广东省新药筛选重点实验室； Rational Medication Evaluation and Drug Delivery Technology Lab, Nanfang Hospital, Southern Medical University；

【摘要】 Aim To raise some questions for peer reference and the development of pharmaceutics by analyzing the problems in developing dosage forms due to the negligence of patent medicine on current pharmaceutical researches. Methods The report was written based on the author’s decades-long experience of engaging in pharmaceutical research as well as his understandings after reading a lot of the published and the pharmaceutics-related documents. Results Issues in the development of new drug delivery system with patent medicine as the aim were as the followings:(1)Direct cell experiments on the constructed drug delivery system to verify the efficacy of the drug delivery system in fact was a waste of scientific fund.(2)The tiny changes of the mother structure of some medicines cause great change in pharmacological effect, which hinted that the function and property of drug carriers might be altered after its molecule structures were modified. However, many studies on carriers-based drug delivery system overlooked it.(3)The development of a new drug carrier is expected to improve the efficiency of intravenous injection while the request for the quality of the in vein injection was often ignored.(4)Whether the effective treatment is from the new constructed drug system itself or just from the synergism/antagonism between the test medicine and the carrier components was very confusing in many published manuscripts.(5)The tissue distribution concentration of a newly developed drug delivery system was often regarded as its targeting effect of the system, which misled researchers in some ways.(6)Many researches claimed that the aims were to improve the oral bioavailability of the test medicine, which was found of no absolute necessity.(7)The design and the experimentation concerning multi-drug delivery system in some published manuscripts were lack of scientific and rigorous considerations. Conclusion It is imperative to know what administration route is taken when a new dosage form is being developed. Second, the ideal test sample form to check its effect on the various cells should be the one reachable to the cell’s site other than just the original developing dosage form. Third, the changing relationships in the function and the characteristic should be taken into consideration when the structures of the carrier were modified in the development of a drug delivery system. In addition, special and reasonable methods need to be set up to evaluate those drug delivery systems in which two or more medicines are simultaneously inserted. Based on the analysis above, it is encouraged for the researchers to develop a new drug delivery system with the aim of patent medicine.更多还原

【Abstract】 Aim To raise some questions for peer reference and the development of pharmaceutics by analyzing the problems in developing dosage forms due to the negligence of patent medicine on current pharmaceutical researches. Methods The report was written based on the author’s decades-long experience of engaging in pharmaceutical research as well as his understandings after reading a lot of the published and the pharmaceutics-related documents. Results Issues in the development of new drug delivery system with patent medicine as the aim were as the followings:(1)Direct cell experiments on the constructed drug delivery system to verify the efficacy of the drug delivery system in fact was a waste of scientific fund.(2)The tiny changes of the mother structure of some medicines cause great change in pharmacological effect, which hinted that the function and property of drug carriers might be altered after its molecule structures were modified. However, many studies on carriers-based drug delivery system overlooked it.(3)The development of a new drug carrier is expected to improve the efficiency of intravenous injection while the request for the quality of the in vein injection was often ignored.(4)Whether the effective treatment is from the new constructed drug system itself or just from the synergism/antagonism between the test medicine and the carrier components was very confusing in many published manuscripts.(5)The tissue distribution concentration of a newly developed drug delivery system was often regarded as its targeting effect of the system, which misled researchers in some ways.(6)Many researches claimed that the aims were to improve the oral bioavailability of the test medicine, which was found of no absolute necessity.(7)The design and the experimentation concerning multi-drug delivery system in some published manuscripts were lack of scientific and rigorous considerations. Conclusion It is imperative to know what administration route is taken when a new dosage form is being developed. Second, the ideal test sample form to check its effect on the various cells should be the one reachable to the cell’s site other than just the original developing dosage form. Third, the changing relationships in the function and the characteristic should be taken into consideration when the structures of the carrier were modified in the development of a drug delivery system. In addition, special and reasonable methods need to be set up to evaluate those drug delivery systems in which two or more medicines are simultaneously inserted. Based on the analysis above, it is encouraged for the researchers to develop a new drug delivery system with the aim of patent medicine.更多还原