【作者】 乔进； 陈霞； 窦志华； 施忠；

【Author】 Chen Zhiqiang;Qiao Jin;Chen Xia;Dou Zhihua;Shi Zhong;Department of Pharmacy,the Third People’s Hospital of Nantong;

【机构】 南通市第三人民医院药学部；

【摘要】 目的了解某院在抗菌药物专项整治活动后抗菌药物合理使用的情况及持续效果,为医院规范围手术期预防使用抗菌药物及建立有效的干预措施提供参考。方法调查某院2016年1-7月全院清洁手术出院病历1432份,对清洁手术预防性使用抗菌药物的使用率、用药品种选择规范率、抗菌药物使用频率与类别、术前给药时机符合率及预防用药总时间进行评价。结果 2016年1-7月某院妇产科、肝胆外科、骨科二病区、骨科一病区、普外科、乳腺外科、泌尿外科及脑外科清洁手术抗菌药物预防使用率分别为58.46%、16.22%、49.47%、55.90%、7.94%、16.22%、73.33%及76.47%,预防用药品种规范率分别为97.37%、72.22%、74.19%、75.93%、90.00%、91.67%、72.73%及96.15%,全院清洁手术抗菌药物预防使用率为41.55%,预防用药品种规范率为78.66%。2016年1-7月某院抗菌药物使用频率较高的为头孢菌素类,其中排名前三的为头孢呋辛(34.62%)、头孢硫脒(33.45%)及头孢他啶(18.66%),分别属于第二代、第一代与第三代头孢菌素。全院清洁手术术前给药时机在0.5-1h占总数的88.57%,其中24h停药率为14.12%,48h停药率为25.38%。结论清洁手术预防使用抗菌药物的给药时机情况较好,抗菌药物的使用率、品种的选择及使用疗程都存在一定的不合理性。更多还原

【Abstract】 Objective To investigate the situation of rational use of antibiotics in a hospital after special rectification activities, and to provide reference for the prevention and treatment of the use of antibiotics in perioperative period and to establish effective intervention measures. Methods Investigate clean surgery 1432 medical records of clean operation from Jan to July during 2016 of a hospital, preventive use of antimicrobial drug use rate, drug selecting standard rate, antimicrobial drug use frequency and categories, the time of preoperative administration in accordance with evaluation rate and the total time of preventive medication. Results Department of Obstetrics and Gynecology, Department of hepatobiliary surgery, Department of orthopedics, Department of orthopedics ward two ward, Department of general surgery, Department of Urology, Department of cerebral surgery, breast surgery and clean surgical antimicrobial prophylaxis use rates were 58.46%, 16.22%, 49.47%, 55.90%, 7.94%, 16.22%, 73.33% and 76.47%, drug varieties and specification rate were 97.37%, 72.22%, 74.19%, 75.93%, 90%, 91.67% 72.73% and 96.15% prevention, clean surgical hospital antibiotic use was 41.55% preventive drugs, drug prevention rate of 78.66% varieties of specifications. 2016 1-7 months in a hospital antibiotic use high frequency cephalosporin, one of the top three for cefuroxime(34.62%), cefathiamidine(33.45%) and ceftazidime(18.66%), which belongs to the second generation, the first generation and the third generation cephalosporins. The cleaning operation time of preoperative administration accounted for 88.57% of the total 0.5-1 h, which 24 h discontinuation rate was 14.12%, the 48 hwithdrawal rate is 25.38% from Jan to July during 2016 of a hospital. Conclusion The opportunity of cleaning operation to prevent the use of antibiotics is good, the usage rate of the antibacterial drugs, the choice of variety and the use of the course of treatment are not reasonable.更多还原