【作者】 刘娟； 王朝明； 刘智； 安行思； 孟庆国；

【Author】 LIU Juan;WANG Chao-ming;LIU Zhi;AN Xing-si;MENG Qing-guo;School of Pharmacy,Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University),Ministry of Education,Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong,Yantai University;

【机构】 烟台大学新型制剂与生物技术药物研究山东省高校协同创新中心分子药理和药物评价教育部重点实验室(烟台大学)；

【摘要】 目的:设计、合成氟康唑衍生物,测定其体外抗真菌活性。方法:基于前期计算机辅助药物研究结果,结合Lipinski类药原则,以氟康唑为先导化合物,保留其母体结构的必需药效团,合成氟康唑衍生物,测定其体外抗真菌(8株真菌)活性。结果:共合成13个新化合物,结构经1H NMR、ESI-MS确证;结论:化合物5e对7种真菌都表现出了较好的抗真菌活性(烟曲霉菌除外),化合物5a、5c、5d、5f、5h、5i、5m对不同真菌表现出了一定的抗真菌活性。更多还原

【Abstract】 OBJECTIVE To design and synthesize fluconazole derivatives, determine the antifungal activity in vitro. METHODS: Based on computer aided drug early, combined with Lipinski medicine principle, using fluconazole as lead compounds, preserving the necessary pharmacophore its parent structure, we synthesize fluconazole derivatives and determine the antifungal activity(8 strains) in vitro. RESULTS: 13 new compounds are synthesized and confirmed by 1 H NMR, ESI-MS. CONCLUSION: Compound 5 e has showed good antifungal activity(except Aspergillus fumigatus) on 7 species of fungi, compound 5 a, 5 c, 5 d, 5 f, 5 h, 5 i, 5 m showed a certain antifungal activity on different fungi.更多还原