【作者】 王倩； 徐偲； 程喆； 郭骧； 李文文； 王兴； 崔红梅； 金建秋； 韩莹； 刘宏伟；

【Author】 Qian Wang;Si Xu;Zhe Cheng;Xiang Guo;Wen-wen Li;Xing Wang;Hong-mei Cui;Jian-qiu Jin;Ying Han;Hongwei Liu;Department of Oral Medicine and Traditional Chinese Medicine, Peking University School and Hospital of Stomatology;

【机构】 北京大学口腔医学院口腔黏膜科；

【摘要】 目的口腔扁平苔藓的病因及发病机制尚不明确,可能与多种因素有关,如感染因素、精神神经因素、遗传因素、免疫学因素、系统性疾病等。本研究对北京大学口腔医院口腔黏膜科确诊的490例口腔扁平苔藓患者病历资料进行回顾性分析,旨在分析口腔黏膜扁平苔藓的患病情况及分布特点,探讨疾病发病、进展相关危险因素,为其诊疗、预防提供参考。方法诊断标准参照《口腔黏膜病学》(第一版,北京大学医学出版社),选取北京大学口腔医院口腔黏膜科门诊自2010年7月至2017年8月490例经临床及病理确诊为口腔扁平苔藓的患者,收集其初、复诊临床资料。采用随机抽样方法,选取同期来院检查口腔黏膜正常者200例纳入对照组,两组人群年龄、性别、职业与文化水平等临床资料差异无统计学意义(P>0.05)。通过问卷调查形式收集对照组人群一般情况及相关危险因素信息。采用spss16.0统计软件包进行分析,以P<0.05为差异有统计学意义。结果 490例患者中男性148例(30.2%),女性患者342例(69.9%)。男女比例大致为1:2。490例OLP患者年龄分布为11～77岁,其中以40-50年龄段高发。OLP的累计部位依次为颊部、舌背、舌腹、唇部、牙龈等。OLP的发生与高血压的患病相关(P<0.05)。其中性别、年龄、高血压、甲状腺疾病、糖尿病进入了logistic的回归模型,对OLP发生的影响程度由大到小依次为性别、年龄、甲状腺疾病、糖尿病、高血压。结论:性别、年龄、甲状腺疾病、糖尿病和高血压等是口腔扁平苔藓的相关因素。关注患者的全身系统性疾病情况对口腔扁平苔藓的诊疗、预防具有重要作用。更多还原

【Abstract】 Objective: The etiology and pathogenesis of oral lichen planus planus are not clear, which may be related to a variety of factors, such as infection factor, mental nerve factor, genetic factor, immunological factor and systemic disease. This study of oral mucosa of hospital of Beijing university oral confirmed 490 cases of oral squamous mosses, patient medical records were retrospectively analyzed, this article aims at analyzing the prevalence of oral mucosa compressed moss and distribution characteristics of disease onset and progress of related risk factors is discussed, and provide reference for its treatment and prevention. Methods Diagnostic criteria with reference to the epidemiology of the oral mucosa(the first edition, Beijing medical university press), the selection of the oral mucosa of hospital of Beijing university oral outpatient service since July 2010 to August 2017, 490 cases of the clinical and pathological diagnosis of patients with oral cavity compressed moss, collected at the beginning of the clinical data and follow-up. Selected by random sampling method, at the same time to hospital check normal oral mucosa, 200 cases in control group, two groups of age, gender, occupation and culture level clinical data such as there was no statistically significant difference(P > 0.05). The general situation and relevant risk factors of the control group were collected through questionnaire. Spss16.0 statistical software package was used for analysis, and P < 0.05 was considered as a statistically significant difference. Results Of the 490 patients, 148 were males(30.2%) and 342 were females(69.9%). The male-female ratio is roughly 1:2. The age distribution of 490 OLP patients ranged from 11 to 77 years old, with a high incidence between 40 and 50 years old. The accumulative parts of OLP were buccal, dorsal tongue, lingual abdomen, lips, gums, etc. OLP was associated with hypertension(P < 0.05). Including gender, age, diabetes, high blood pressure, thyroid disease into the logistic regression model, the influence degree of OLP from big to small in turn for gender, age, thyroid disease, diabetes, high blood pressure. Conclusion:Sex, age, thyroid disease, diabetes and hypertension are risk factors for oral lichen planus. Paying attention to the systemic disease of the patient is of great importance to the diagnosis and prevention of orallichen planus.更多还原