Tunable synthesis of functionalized cyclohexa-1,3-dienes and 2-aminobenzophenones/benzoate from the cascade reactions of allenic ketones/allenoate with amines and enones

【作者】 丰田； 田苗苗； 范学森；

【Author】 Tian Feng;Miaomiao Tian;Xuesen Fan;School of Chemistry and Chemical Engineering,Henan Normal University;

【机构】 河南师范大学化学化工学院；

【摘要】 A TEMPO-dependent tunable synthesis of functionalized cyclohexa-1,3-dienes and 2-aminobenzophenones/benzoate from the one-pot cascade reactions of allenic ketones/allenoate with amines and enones is presented. Mechanistically, the construction of the entitled six-membered carbocycles involves the in situ generation of an enaminone intermediate via the conjugate addition of allenic ketone with amine followed by its catalyst-and base-free [3+3] annulation with enone along with the simultaneous introduction of the valuable amino and carbonyl groups.更多还原

【Abstract】 A TEMPO-dependent tunable synthesis of functionalized cyclohexa-1,3-dienes and 2-aminobenzophenones/benzoate from the one-pot cascade reactions of allenic ketones/allenoate with amines and enones is presented. Mechanistically, the construction of the entitled six-membered carbocycles involves the in situ generation of an enaminone intermediate via the conjugate addition of allenic ketone with amine followed by its catalyst-and base-free [3+3] annulation with enone along with the simultaneous introduction of the valuable amino and carbonyl groups.更多还原