【作者】 唐慧； 潘志雄； 付茂忠； 易军； 易礼胜； 邓由飞； 甘佳； 王淮；

【Author】 Tang Hui;Pan ZhiXiong;Fu MaoZhong;Yi Jun;Yi LiSheng;Deng YouFei;Gan Jia;Wang Huai;Sichuan Animal Science Academy;Institute of Animal Genetics and Breeding, Sichuan Agricultural University;

【机构】 四川省畜牧科学研究院； 四川农业大学动物遗传育种研究所；

【摘要】 RNA干扰(RNAi)是指双链RNA(ds RNA)诱导同源靶基因的m RNA特异性降解或翻译抑制,而导致转录后基因沉默的现象。RNA介导的沉默复合体(RISC)在RNAi中起着重要的作用,而Argonaute蛋白又是该复合体中的关键蛋白,它剪开双链小RNAs,并引导其主链即介导链与靶m RNA互补配对,从而使靶m RNA降解或者抑制靶m RNA的翻译。本文就Argonaute蛋白家族与小RNA之间的关系及Argonaute蛋白家族在小RNAs介导的基因沉默中的作用进行综述。更多还原

【Abstract】 RNA interference(RNAi) refers to homologous target m RNA degradation induced specifically by double-stranded RNA,thereby leads to post-transcriptional gene silencing. RNA-induced silencing complex(RISC) mediated by RNA plays animportant role in RNAi. Argonaute proteins are the key component of the RISC,which release the mature mi RNA from double-stranded RNA complex, and pairs the mi RNA with the target m RNA.The target m RNA is degraded or translationally repressed. In this review, we present the recent progress in relationship between Argonaute proteins and mi RNAs and the role of mediated gene silencing.更多还原