The safety profile of subcutaneous allergen immunotherapy in children with atopic dermatitis in Hangzhou,East China

【作者】 宁维翾； 刘金玲； 任金平； 杨敏；

【机构】 杭州市中医院皮肤科； 浙江大学附属儿童医院呼吸科；

【摘要】 目的:The aim of the current study is to evaluate the prevalence,severity and possible risk factors of systemic reactions(SRs) to subcutaneous allergen immunotherapy(SCIT) in children and adolescents with atopic dermatitis(AD) in Hangzhou,east China’s Zhejiang province.方法:From January2012 to December 2016,this survey analyzed the SCIT-related SRs involving 307 patients(189 children and 118 adolescents) affected by AD.Recorded data included demographics,diagnosis,patient statuses,before and after each injection,allergen dosage,and details of SRs.结果:All patients finished the initial phase and 2 patients withdrew during the maintenance phase.There were 2.61%(239/9156) SRs in all injections(3.57%in children and 1.39%in adolescents);15.96%(49/307) patients experienced SRs(19.52%children and 9.79%adolescents).There were 55.65%SRs of grade 1,41.42%SRs of grade 2,2.93%SRs of grade 3,and no grades 4 or grade 5 SRs occurred in patients.Most reactions were mild,and were readily controlled by immediate emergency treatment.There was no need for hospitalization.The occurrence of SRs was significantly higher in children than that in adolescents(p<0.01).A higher ratio of SRs was found among patients with asthma.结论:This retrospective survey showed that properly conducted SCIT was a safe treatment for children and adolescents with AD in Hangzhou,East China.Children and patients with asthma may be prone to develop SRs.更多还原

【Abstract】 目的:The aim of the current study is to evaluate the prevalence,severity and possible risk factors of systemic reactions(SRs) to subcutaneous allergen immunotherapy(SCIT) in children and adolescents with atopic dermatitis(AD) in Hangzhou,east China’s Zhejiang province.方法:From January2012 to December 2016,this survey analyzed the SCIT-related SRs involving 307 patients(189 children and 118 adolescents) affected by AD.Recorded data included demographics,diagnosis,patient statuses,before and after each injection,allergen dosage,and details of SRs.结果:All patients finished the initial phase and 2 patients withdrew during the maintenance phase.There were 2.61%(239/9156) SRs in all injections(3.57%in children and 1.39%in adolescents);15.96%(49/307) patients experienced SRs(19.52%children and 9.79%adolescents).There were 55.65%SRs of grade 1,41.42%SRs of grade 2,2.93%SRs of grade 3,and no grades 4 or grade 5 SRs occurred in patients.Most reactions were mild,and were readily controlled by immediate emergency treatment.There was no need for hospitalization.The occurrence of SRs was significantly higher in children than that in adolescents(p<0.01).A higher ratio of SRs was found among patients with asthma.结论:This retrospective survey showed that properly conducted SCIT was a safe treatment for children and adolescents with AD in Hangzhou,East China.Children and patients with asthma may be prone to develop SRs.更多还原