【作者】 庞焯月； 叶自华； 王晨阳； 刘楠； 甘怡群；

【Author】 PANG Zhuoyue;YE Zihua;WANG Chenyang;LIU Nan;GAN Yiqun;Department of Applied Psychology, Peking University;Department of Psychology, Rice University;Department of Psychology, McGill University;Department of Sociology, Peking University;

【机构】 北京大学应用心理学系； 莱斯大学心理学系； 麦吉尔大学心理学系； 北京大学社会学系；

【摘要】 癌症风险告知指对有可能携带突变癌症基因的患者进行基因检测,从而告知其患癌的风险程度。为研究癌症风险告知对患者焦虑情绪的影响,以及被试因素(家族病史、是否接受干预和年龄)、客观因素(出版年份和国家)和告知因素(癌症基因检测类型、癌症风险告知结果和癌症风险告知后测量时间长短)的调节作用,利用Comprehensive Meta-Analysis 2.0软件,对13篇英文文献(包括28个样本,被试共2298人)进行了元分析。结果发现:(1)总体效果量为-0.29,癌症风险告知后被试的焦虑水平显著下降。(2)亚组分析发现,所有亚组癌症风险告知后被试的焦虑水平都有所下降,但显著性有差异,除了癌症基因检测类型无显著差异外,其他亚组均有显著性差异。(3)元回归分析发现,随着平均年龄的增加,癌症风险告知后被试焦虑的下降程度增大;但出版年份的影响不显著。结果表明:家族病史、是否接受干预、年龄、国家、癌症风险告知结果和癌症风险告知后测量时间长短对总体效果量有调节作用,未来对患者癌症风险告知期间的焦虑情绪干预应重视上述调节变量对干预效果的影响,并进一步研究癌症风险告知对患者抑郁、心理应激反应和心理控制等其他心理问题的影响,从而对癌症风险告知期间患者心理问题的干预提出更为有效的建议。更多还原

【Abstract】 Cancer risk disclosure means administering genetic testing with patients potentially carrying cancer genes to inform risks of developing cancer. In order to understand the effects of disclosure, and moderating effects of patients’ background(family history, engagement in intervention, and age), contextual factors(year of publication and nationality), and nature of disclosure(genetic testing type, outcome, post-disclosure assessment point), on anxiety level, a meta-analysis of 13 papers(including 28 samples and 2298 participants) is conducted using Comprehensive Meta-Analysis 2.0. The results show:(1) The total effect size is-.29, which indicates genetictesting disclosure reduces overall level of anxiety significantly.(2) All subgroup patients exhibit lower anxiety level post-disclosure, yet all moderators demonstrate variations despite type of genetic testing.(3) As mean age rises, post-disclosure anxiety level shows significant declines accordingly, but publication year shows no significant effect. Furthermore, the results indicate: family history, engagement in intervention, age, nationality, testing outcomes, and post-disclosure assessment point all act as significant moderators to the total effect size. In the future, interventions on anxiety during processes of cancer risk disclosure should pay close attention to the aforementioned moderators’ holistic impact on intervention outcome. In addition, future studies should investigate cancer risk disclosure’s effect on depression, stress, locus of control, and other aspects of psychological well-being, to provide insights into patient mental health over the cancer risk disclosure phase.更多还原