【作者】 田娜娜； 田纳； 李超； 周前雄； 张宝文； 王雪松；

【Author】 Nana Tian;Na Tian;Chao Li;Qian-Xiong Zhou;Bao-Wen Zhang;Xue-Song Wang;Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences;

【机构】 中国科学院光化学转换与光电功能材料重点实验室中国科学院理化技术研究所；

【摘要】 麦角固醇内过氧化物（EEP）已被证实具有提高免疫力、抗癌、消炎等生物活性^[1-2]。作为麦角固醇内过氧化物的类似物,7-去氢胆固醇内过氧化物（CEP）的生物活性目前还未被报道。我们首次合成和分离得到了CEP,与EEP相比,CEP表现出更好的抗癌活性和对肿瘤细胞的选择性。更多还原

【Abstract】 Ergosterol peroxide(5α,8α-epidioxy-22 E-ergosta-6,22-dien-3β-ol, EEP) has shown a variety of biological effects, such as anti-inflammatory, antibacterial, and anti-tumor activities. However, the biological activities of 7-dehydrocholesterol peroxide(5α,8α-epidioxycholest-6-ene-3β-ol, CEP), an analogue of EEP, is unknown yet. In this work, CEP was synthesized and isolated for the first time, which exhibits improved anticancer activity and selectivity over EEP, showing potential as a new chemotherapeutic agent.更多还原