【作者】 徐林艳； 任志刚；

【Author】 Lin-Yan Xu;Zhi-GangRen;College of Chemistry, Chemical Engineering and Materials Science, Soochow University;

【机构】 苏州大学材料与化学化工学部；

【摘要】 在C-C偶联反应当中,Suzuki–Miyaura交叉偶联反应是比较重要的一种反应类型^[1]。相比于溴戒碘代芳基底物而言,氯代芳基底物活性较低,反应条件更苛刻^[2]。本文合成了一种基于P,N混合配体N-二苯基膦-2-氨基吡啶（L₁）的双齿钯化合物[（L₁）PdCl₂]（1）,幵对其结构迚行测定。化合物1能够高效地催化丌活泼的氯代芳基化合物与芳基硼酸的Suzuki–Miyaura交叉偶联反应。相比于单齿戒双齿膦配体而言,N-二苯基膦-2-氨基吡啶在本体系中的催化效果更好。其底物适用性广,大部分反应产率较高。更多还原

【Abstract】 There have been major efforts in the past decades to developefficient catalysts for the Suzuki-Miyaura crosscoupling reaction.1 Aryl chloride analogues generallygo less reactive and require harsher conditions and/or longer reactiontimes to give the coupling products in lower yields.2 In this paper, one palladium dichloride adduct[（L₁）PdCl₂]（1） of a phosphine-pyridine ligandN-diphenylphosphanyl-2-aminopyridine（L₁） has been prepared and structurally characterized. Compound 1 can beused as an effective catalyst for the SuzukiMiyaura cross-coupling reactions of unreactive aryl chlorides with arylboronic acids, and worked much better than its mono-or bidentate phosphine ligands. The reactions with a wide scope of substrates proceeded to give desired products in good to excellent yields.更多还原