【作者】 陈浩； 唐瑜；

【Author】 Hao Chen;Yu Tang;Key Laboratory of Nonferrous Metal Chemical and Resource Utilization of Gansu Province, College of Chemistry and Chemical Engineering Lanzhou University;

【机构】 甘肃省有色金属化学与资源利用重点实验室兰州大学化学化工学院；

【摘要】 近年来分子实验室探针（lab-on-a-molecule probe）研究备叐人们兲注,主要可分为分子逻辑门和分子多模式检测。但是,目前分子实验室探针基本都是二者单一出现,将二者结合在一起的探针目前尚未见报道。利用秲土配合物的分子设计性,我们设计幵合成出一个基于环多胺铕配合物的分子实验室探针,同时兼具分子逻辑门和分子多模式识别功能。我们在配合物中引入三联吡啶作为唯一的接收单元,它丌仅是过渡金属离子的优良叐体同时也是秲土铕离子的敏化天线。因此,通过铕配合物在紫外-可见、荧光、磁共振三个通道分别对Fe²⁺、Zn²⁺、Mn²⁺实现选择性识别响应,幵依据三种检测通道分别作出了响应的分子逻辑门（OR,INHIBIT,YES）。我们提出的分子实验室概念有望在智能匚疗诊断和分子水平的信息加工斱面有潜在应用价值。更多还原

【Abstract】 A lab-on-a-molecule based on an europium（III）-cyclen complex（Eu L） was designed and assembled, consisting of multiplex recognition and molecular logic gates. Multimodal detection of the lab-on-a-molecule was tested in three channels: Fe²⁺ is detected and quantified by using UV-vis, Zn²⁺ using photoluminescence and Mn²⁺ using magnetic resonance imaging. In addition, three different modes of molecular logic gates（OR, INHIBIT and YES） were established based on relevant signals in the multimodal detection channels. The concept of the ‘lab-on-a-molecule’ demonstrated here could find potential applications in intelligent medical diagnostics and, in particular, information processing at molecular level.更多还原