节点文献
脱氧胆酸钠超分子凝胶的制备及其性能研究
Preparation and Characterization of Supramolecular Gel Based on SodiumDeoxycholate
【Author】 Yi Guo;Shuai Jie;Ya-Zhuo Shang;Hong-Lai Liu;Key Laboratory for Advanced Materials,School of Chemistry & Molecular Engineering,East China University of Science and Technology;
【机构】 华东理工大学结构可控先进功能材料及其制备教育部重点实验室;
【摘要】 作为一类重要的软材料,超分子凝胶在药物运输、生物材料、生物分离和染料吸附等领域有着广阔的应用前景,并在近年来受到了广泛的关注。胆汁酸及其盐不仅是一大类生物表面活性剂,也是重要的生物小分子凝胶因子,可以作为包括人在内的脊椎动物肠内部的胆固醇、胆红素、和多种脂溶性维他命的增溶剂。我们选用脱氧胆酸钠(NaDC)为研究对象,对其与L-天冬氨酸(Asp)复配体系的凝胶化行为及性质进行了研究,考察聚合物的引入对凝胶体系性质的影响。研究发现,凝胶网络结构的形成是氢键、疏水作用、静电作用及范德华力共同驱动的结果。Asp的加入可以导致体系发生溶胶-凝胶的转变;无规共聚物聚(2-(2-甲氧基乙氧基)甲基丙烯酸乙酯-co-寡聚(乙二醇)甲基醚甲基丙烯酸酯)(P(MEO2MA90-co-OEGMA10))和星形聚合物聚(N,N-二甲胺基甲基丙烯酸乙酯-b-2-(2-甲氧基乙氧基)甲基丙烯酸乙酯)(CDPDPM)可参与凝胶网络结构的形成,使凝胶的网络结构更加致密,导致机械强度提高。通过调整聚合物的性质及浓度等有望实现对凝胶机械强度的调控。该体系在超分子凝胶及软物质材料等领域展现出独特的应用潜力。
【Abstract】 As an important series of soft materials,supramolecular hydrogels have received considerable attention in recent years because of their great potentials in different areas including drug delivery,biomaterials,biological separation,removal of toxic dyes,etc.Bile acids and their salts are important biological surfactants and small molecule biological gelators that can act as solubilizers of cholesterol,bilirubin,and various fat-soluble vitamins in the intestine of vertebrates,including humans.Herein,we report the gelation behavior and properties of sodium deoxycholate(NaDC) with L-Aspartic acid(Asp) in aqueous solution.Also the influence of polymer on the properties of hydrogels is studied.The results show that the main driving forces for the formation of hydrogels are considered to be hydrogen bonding as well as electrostatic interaction,hydrophobic interaction and van der Waals force.With increasing the concentration of Asp in the system,the transition from sol to gel is observed.The random copolymer poly(2-(2-methoxyethoxy)ethyl methacrylate-co-oligo(ethylene glycol) methacrylate)(P(MEO2 MA90-co-OEGMA10)) and star-shaped block polymer poly(2-(dimethylamino)ethyl methacrylate-b-2-(2-methoxyethoxy)ethyl methacrylate)(CDPDPM) can participate in the formation of gel network structure,so that the density of network structure and the mechanical strength of hydrogels increase.By adjusting the properties and concentrations of the polymers,it is expected to control the mechanical strength of the hydrogels.This gel system exhibits unique application potential in the fields of supramolecular gel and soft material.
- 【会议录名称】 中国化学会第十六届胶体与界面化学会议论文摘要集——第三分会:软物质与超分子自组装
- 【会议名称】中国化学会第十六届胶体与界面化学会议
- 【会议时间】2017-07-24
- 【会议地点】中国山东青岛
- 【分类号】O648.17
- 【主办单位】中国化学会