Studies toward the Application of Peptide Amphiphile Self-Assembly in TACA-based Vaccine Development

【作者】 王颖璐； Xiujing Zheng； Yaohao Li； 杨冰； Ning Yuan； 叶新山； Suwei Dong；

【Author】 Yinglu Wang;Xiujing Zheng;Yaohao Li;Bing Yang;Ning Yuan;Xinshan Ye;Suwei Dong;State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University;

【机构】 State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University； 北京大学；

【摘要】 <正>Tumor-associated carbohydrate antigen(TACA)has drawn significant attention as a target of cancer identification and immunotherapy.Tn antigen(N-acetylgalactosamine-O-glycosides of serine or threonine)are overexpressed on cancer cells of human adenocarcinomas,and lung,colon,and stomach cancers.However,carbohydrates alone can not activate helper T lymphocytes and have limited更多还原