Total synthesis of mycobacterial arabinogalactan containing 92 monosaccharide units

【作者】 吴勇； 熊德彩； Si-Cong Chen； Yong-Shi Wang； 叶新山；

【Author】 Yong Wu;De-Cai Xiong;Si-Cong Chen;Yong-Shi Wang;Xin-Shan Ye;State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University;

【机构】 北京大学； State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University；

【摘要】 <正>Carbohydrates are diverse bio-macromolecules with highly complex structures that are involved in numerous biological processes,such as cell signaling,cell proliferation and differentiation and viral and bacterial infections,as well as immunoresponse.Well-defined carbohydrates obtained by chemical synthesis are essential to the understanding of their functions.However,synthesis of carbohydrates is greatly hampered by its insufficient efficiency.So far,assembly of long carbohydrate chains remains one of the most challenging tasks for synthetic更多还原