含喹喔啉的腙类化合物的合成与杀菌活性

【作者】 汪乔； 沈钟华； 谭成侠； 翁建全； 刘幸海；

【机构】 浙江工业大学农药研究所；

【摘要】 [目的]腙类和喹喔啉类化合物因具有独特的生物活性,一直是绿色农药创制研究的热点之一,为寻找新型高效的杀真菌剂。[方法]本文在苯并吡嗪结构上拼接上C=N结构,设计并合成了一系列含喹喔啉的腙类化合物。[结果]合成出9个未见报道的喹喔啉腙类化合物,所合成的化合物均进行了~1H NMR和HRMS表征,并对这些化合物做了初步的杀菌活性测试。[结论]大部分化合物表现出杀菌活性,其中以4a,4b,4c三种化合物杀菌活性最佳,对尖孢炭疽菌,草莓炭疽菌,枸杞炭疽病菌均有良好的杀菌活性。更多还原

【Abstract】 [Aims]The aims were to find the new and effective fungicide.[Methods]The structure of C=N was stitched on the structure of benzo pyrazine,and a series of hydrazones were designed containing quinoxaline moiety.[Results]Totally 13 novel target compounds were synthesized.Their structures were confirmed by ~1H NMR and HRMS.The biological activities of these compounds were evaluated.[Conclusions]The antifungal activities results showed that these compounds have activity to against Fungus,5a,5b,5c behaved the best antifungal activity.更多还原