【作者】 胡崇波； 杜晓华；

【Author】 HU Chong-bo;DU Xiao-hua;Catalytic Hydrogenation Research Center,Zhejiang Key Laboratory of Green Pesticides and Cleaner Production Technology,Zhejiang University of Technology;

【机构】 浙江工业大学催化加氢中心浙江省绿色农药清洁生产技术研究重点实验室浙江省绿色农药协同创新中心；

【摘要】 [目的]为改善双酰肼类杀虫剂的性能。[方法]依据生物合理设计原理,将吡啶环引入双酰肼的基本结构中。[结果]设计合成了一系列烟酰酰肼类新化合物,经~1H-NMR、瓜和HRMS的确证了分子结构,并进行初步的生物活性测试。[结论]生物活性测试表明:大部分化合物对东方粘虫具有一定的活性的,化合物12bc,12bd,12be,12bf在500 mg/L的浓度下对东方粘虫的致死率为100%。所得结果可为N-叔丁基-N′-(2-取代吡啶甲酰基)-取代酰肼类化合物构效关系研究提供参考。更多还原

【Abstract】 [Aims]In order to improve diacylhydrazine pesticidal activities against pests.[Methods]According to the bio-rational design principle,introduced pyridine ring into the basic structure of diacylhydrazine.[Results]a series of novel nicotinoylhydrazines were designed and synthesized,the structures of the target compounds were characterized by ~1H NMR,IR and HRMS,they were also texted by preliminary bioassays.[Conclusions]The bioassay results indicated that most of the compounds exhibited some biological activitivies against Mythimna separata.These results provided further insights into the relationship between the structures and biological activityof this novel N-(tert-butyl)-N’-(2-substitutednicotinyl)-substitutedhydrazines更多还原