Electroacupuncture stimulation of the brachial plexus trunk on the healthy side promotes brain-derived neurotrophic factor mRNA expression in the ischemic cerebral cortex of a rat model of cerebral ischemia/reperfusion injury

【作者】 郭宗君； 王鲁民；

【Author】 Zongjun Guo;Lumin Wang;Department of Health Care,Affiliated Hospital of Qingdao University;Department of Emergency Treatment,Affiliated Hospital of Qingdao University;

【机构】 青岛大学附属医院保健科&老年医学科； Department of Emergency Treatment,Affiliated Hospital of Qingdao University；

【摘要】 A rat model of cerebral ischemia/reperfusion was established by suture occlusion of the left middle cerebral artery.In situ hybridization results showed that the number of brain-derived neurotrophic factor mRNA-positive cells in the ischemic rat cerebral cortex increased after cerebral ischemia/reperfusion injury.Low frequency continuous wave electroacupuncture(frequency 2-6 Hz,current intensity 2 mA) stimulation of the brachial plexus trunk on the healthy(right) side increased the number of brain-derived neurotrophic factor mRNA-positive cells in the ischemic cerebral cortex 14 days after cerebral ischemia/reperfusion injury.At the same time,electroacupuncture stimulation of the healthy brachial plexus truck significantly decreased neurological function scores and alleviated neurological function deficits.These findings suggest that electroacupuncture stimulation of the brachial plexus trunk on the healthy(right) side can greatly increase brain-derived neurotrophic factor mRNA expression and improve neurological function.更多还原

【Abstract】 A rat model of cerebral ischemia/reperfusion was established by suture occlusion of the left middle cerebral artery.In situ hybridization results showed that the number of brain-derived neurotrophic factor mRNA-positive cells in the ischemic rat cerebral cortex increased after cerebral ischemia/reperfusion injury.Low frequency continuous wave electroacupuncture(frequency 2-6 Hz,current intensity 2 mA) stimulation of the brachial plexus trunk on the healthy(right) side increased the number of brain-derived neurotrophic factor mRNA-positive cells in the ischemic cerebral cortex 14 days after cerebral ischemia/reperfusion injury.At the same time,electroacupuncture stimulation of the healthy brachial plexus truck significantly decreased neurological function scores and alleviated neurological function deficits.These findings suggest that electroacupuncture stimulation of the brachial plexus trunk on the healthy(right) side can greatly increase brain-derived neurotrophic factor mRNA expression and improve neurological function.更多还原