【作者】 赵海； 姚刚； 钱宁； 陈明飞； 杨智； 吴曙光；

【Author】 ZHAO Hai;YAO Gang;QIAN Ning;CHEN Ming-fei;YANG Zhi;WU Shu-guang;The Laboratory Animal Institute of Guiyang university of Chinese Medicine;

【机构】 贵阳中医学院实验动物研究所；

【摘要】 目的探讨慢性疲劳综合征小鼠与正常小鼠之间空间探索能力的差异性。方法采用复合刺激法复制慢性疲劳综合征(Chronic Fatigue Syndrome,CFS)小鼠模型,随后观察CFS小鼠与正常组小鼠在旷场装置中的活动情况。结果与对照组小鼠相比较,模型组小鼠在旷场装置中的活动总路程和平均活动速度均低于对照组小鼠;在周边区域的活动路程显著性低于对照组小鼠(P<0.05);而在中央区域活动的总时间和路程显著性均高于对照组小鼠(P<0.05)。结论CFS小鼠的自发活动和探索行为能力降低,并且其避趋性和焦虑水平增高。更多还原

【Abstract】 Objective To study the differences of space exploration ability between chronic fatigue syndrome mice and normal mice. Method First of all, the Chronic Fatigue Syndrome(Chronic Fatigue Syndrome, CFS) mouse model is copied by using compound stimulus method, and then to explore the activity in the open field devices between chronic fatigue syndrome mice and normal mice. Result The total distance moved and average movement speed in the open field devices was decreased in chronic fatigue syndrome group compared with the normal group; The distance in the out ring was significant decreased in chronic fatigue syndrome group compared with the normal group(P<0.05); However the duration of movement and distance in the area was significant higher than control group(P<0.05). Conclusion The ability of spontaneous and exploratory behavior was reduced in CFS mice, which the levels of avoid tropism and anxiety was increased.更多还原