【作者】 饶子亮； 王弋； 王诺； 熊仁清； 张明浩； 邝少松； 唐小江； LOU Cai-xia；

【Author】 RAO Zi-liang;WANG Yi;WANG Nuo;XIONG Ren-qing;ZHANG MING-hao;LOU Cai-xia;KUANG Shao-song;TANG Xiao-jiang;GuangDong Medical Laboratory Animal Center;Tianda Pharmaceuticals Limited;

【机构】 广东省医学实验动物中心； 天大药业(珠海)有限公司； GuangDong Medical Laboratory Animal Center；

【摘要】 目的研究以新型聚乳酸磷酸酯共聚物(PLCE)为载体的紫杉醇缓释微球体内抑瘤效果。方法采用HO8910人卵巢癌细胞株,手术接种于68只BALB/c裸小鼠卵巢包膜下。3周后,取肿块大小相对均匀的42只裸小鼠随机分成7组:空白对照组、聚合物空白微球对照组、紫杉醇注射液组,紫杉醇缓释微球1中、低剂量组,紫杉醇缓释微球2中、低剂量组,每组6只。分组当日给药1次,连续观察一个月。结果紫杉醇注射液抑瘤率57.0%;紫杉醇缓释微球2中剂量抑瘤率77.1%,低剂量抑瘤率58.7%。结论以新型聚乳酸磷酸酯共聚物(PLCE)为载体的紫杉醇缓释微球2(60mg/kg)对卵巢癌裸小鼠原位移植瘤有良好的抑制效果,但是毒性仍然较大,需要进一步改进。更多还原

【Abstract】 Objective To observe the influence of paclitaxel-PLCE(Novel copolymer of poly lactic acid phosphate)microspheres on proliferation of Ovarian cancer.Methods HO8910 were implanted into the ovarian capsule of 68 nude mice. Three weeks later, 42 Tumor bearing nude mice were randomly divided into 7 groups as follow, blank control group, negative control group, paclitarel injection group, paclitaxel-Novel copolymer of poly lactic acid phosphate(PLCE) microspheres 1 high and low dose group, and paclitaxel-PLCE microspheres 2 high and low dose group, with 6 in each group. The drug was administered 1 times a day,Continuous observation for a month. Results The tumor inhibition rate of Paclitarel Injection was 57.0%, and tumor inhibition rate of paclitaxel-PLCE microspheres 2 high and low dose group was 77.1% and 58.7% respectively. Conclusion Paclitaxel-PLCE microspheres have a strong inhibitory effect on HO8910 Ovarian cancer transplanted in nude mice.更多还原