【作者】 潘永明； 金平； 徐剑钦； 刘军平； 蔡兆伟； 许茂盛； 陈民利；

【Author】 PAN Yong-ming;JIN Ping;XU Jian-qin;LIU Jun-ping;CAI Zhao-wei;XU Mao-sheng;CHEN Min-li;Laboratory Animal Research Center/Comparative Medical Research Institute, Zhejiang Chinese Medical University;Third Hospital affiliated to Zhejiang Chinese Medical University;First Hospital affiliated to Zhejiang Chinese Medical University;

【机构】 浙江中医药大学动物实验研究中心/比较医学研究所； 浙江中医药大学附属第三医院； 浙江中医药大学附属第一医院；

【摘要】 目的基于3.0 T磁共振成像(MRI)技术,活体观察WHBE兔脑部形态解剖结构,累积WHBE兔脑的影像学基本生物学数据,为进一步拓宽WHBE兔的应用提供背景资料。方法健康成年雄性WHBE兔9只,用3%戊巴比妥钠溶液静脉注射麻醉,行3.0T MRI加兔脑专用线圈常规横断面和矢状面扫描,并测量分析脑部的各种结构大小。结果 MRI扫描可成功获得活体WHBE兔脑矢状面和横断面T2WI或T1WI图像,可完整清晰地观察到活体WHBE兔的嗅球、大脑、小脑和垂体等基本结构,并发现了4只兔脑T2WI中左右两侧颞叶海马区高信号,相应区域在T1WI出现低信号外,其余均无异常。同时,获得了额叶、海马、大脑、侧脑室、垂体等相关解剖结构的参考值。结论采用3.0 T磁共振成像系统加上兔脑专用线圈,可以清晰地观察到WHBE兔脑部的各种形态解剖结构,并初步建立了WBHE兔脑影像学基本数据。更多还原

【Abstract】 Objective To observe the morphological anatomic structure of WHBE rabbit brain in vivo based on the 3.0 T magnetic resonance imaging system(MRI), accumulate the basic biological data of WHBE rabbit brain imaging, and provide background information to further broaden the WHBE rabbit application. Methods 9 healthy adult male WHBE rabbits, intravenous anesthesia with 3% pentobarbital sodium solution, and 3.0 T MRI plus rabbit brain dedicated coil conventional transverse and sagittal scan, and measure the size of brain structure. Results MRI scan can be successfully obtained sagittal and transverse T2WI or T1WI of WHBE rabbit brains in vivo, and also can be clearly observed the basic construction of WHBE rabbit brains in vivo, such as olfactory bulb, cerebrum, cerebellum and pituitary. In addition, high signal was found in the hippocampus of the left and right temporal lobe in 4 rabbits with T2WI, and the corresponding region appeared low signal in T1WI, the others were not abnormal. Meanwhile, the frontal lobe, hippocampus, lateral ventricle, brain, pituitary and other related anatomical references were also obtained. Conclusion Using the 3.0 T magnetic resonance imaging system and the rabbit brain coil can clearly observe the morphological and anatomical structures of the brain in WHBE rabbits, and the basic imaging data of WHBE rabbits were established preliminarily.更多还原