【作者】 陈梅芳； 诸亚萍； 罗伏钢；

【Author】 CHEN Mei-fang;ZHU Ya-ping;LUO Fu-gang;The 7th Hospital in Hangzhou;

【机构】 杭州市第七人民医院；

【摘要】 目的观察艾司西酞普兰联用复方海蛇胶囊治疗血管性痴呆伴发抑郁症状的疗效及对认知功能的影响。方法将符合血管性痴呆伴发抑郁症状诊断标准的64例患者随机分为两组,试验组在口服复方海蛇胶囊的基础上联用艾司西酞普兰,对照组联用帕罗西汀,观察12周。用汉密尔顿抑郁量表(HAND)评定抗抑郁的疗效,用简易智力状态检查(MMSE)评定认知功能。结果治疗2周HAND评分与治疗前相比差异有显著性(P<0.05),4周起差异有非常显著性(P<0.01);对照组治疗4周差异有显著性(P<0.05),8周起差异有非常显著性(P<0.01);治疗2周两组HAND评分差异有显著性(P<0.05)。试验组治疗8周起MMSE评分与治疗前相比差异有非常显著性(P<0.01);对照组治疗8周起差异有显著性(P<0.05);治疗12周两组差异有显著性(P<0.05)。结论艾司西酞普兰和帕罗西汀治疗血管性痴呆伴发抑郁症状均有明显疗效,对认知功能有改善,艾司西酞普兰起效更快,对认知功能改善更明显。更多还原

【Abstract】 Objective To observe the efficacy of escitalopram plus compound sea snakes capsule for depression and cognitive impairment in patients with vascular dementia(VD).Methods 64 VD patients with depressive symptoms conforming to the diagnostic standard were randomly divided into two groups.The experimental group was given compound sea snakes capsule plus escitalopram,and the control group was given compound sea snakes capsule plus paroxetine.The patients were treated and observed for 12 weeks.The Hamilton Depression Scale(HAND) was used for assessment of antidepressant efficacy and Mini Mental State Examination(MMSE)for assessment of cognitive function.Results There was a significant improvement in HAND score after 2 weeks of treatment(P<0.05)and after 4 weeks of treatment(P<0.01) in the experimental group.There was a significant improvement in HAND score after 4 weeks of treatment(P<0.05) and after 8 weeks of treatment(P<0.01) in the control group.There was a significant difference in HAND score between the two groups after 4 weeks of treatment(P<0.05).MMSE score was increased significantly in the experimental group(P<0.01)after 8 weeks of treatment and in the control group(P<0.05).There was a significant difference in MMSE score between the two groups after 12 weeks of treatment(P<0.05).Conclusion The efficacy of escitalopram and paroxetine for depression is obvious in AD patients with depressive symptoms and cognitive function can also be improved by escitalopram and paroxetine.Escitalopram has a faster efficient time and an advantage in improving cognitive function.更多还原