【作者】 燕晓晓； 王军； 吕文发；

【Author】 YAN Xiao-xiao;WANG Jun;LYU Wen-fa;College of Animal Science and Technology,Jilin Agricultural University;

【机构】 吉林农业大学动物科技学院；

【摘要】 子宫内膜炎是奶牛产后细菌感染子宫而引起的产科疾病,严重影响奶牛业的健康发展。革兰氏阴性细菌中的大肠杆菌是目前已知引起奶牛子宫内膜炎的主要致病菌,细菌脂多糖(lipopolysaccharide,LPS)是革兰氏阴性细菌细胞壁的重要组成成分,也是近年来研究奶牛子宫内膜炎发病机制的重要诱导物。本文综述了LPS、TOLL样受体家族(Toll-like receptors,TLRs)及炎性因子,初步剖析了LPS诱导的炎症反应信号传导通路-TLR4信号通路,为奶牛子宫内膜炎的研究提供参考。更多还原

【Abstract】 Postpartum endometritis in cattle is an obstetric disease caused by bacterial infection,which is of economic importance since it negatively impacts on the dairy industry.Gram negative bacteria of Escherichia coli is the main pathogens currently known to cause cow endometritis and bacterial lipopolysaccharide(LPS) is a major component of the cell wall of gram negative bacteria and recently,also reported as an important inducer of cow endometritis pathogenesis.This paper reviews the LPS,toll like receptor family(Toll-like receptors,TLRs) and inflammatory factors as well as preliminary analysis of the LPS induced inflammatory response signaling pathway-TLR4 signaling pathway in order to provide reference for the study of cow endometritis.更多还原