【作者】 杨柳青； 李培福； 冒海瀛； 王惠玲； 舒畅； 周媛；

【Author】 Liuqing Yang;Peifu Li;Haiying Mao;Huiling Wang;Chang Shu;Yuan Zhou;Key Laboratory of Behavioral Science,Institute of Psychology,Chinese Academy of Sciences;University of Chinese Academy of Sciences;Department of Psychiatry,Renmin Hospital of Wuhan University;

【机构】 中国科学院心理研究所行为科学重点实验室； 中国科学院大学； 武汉大学人民医院精神卫生中心；

【摘要】 精神分裂症患者通常具有社会互动障碍,研究其社会互动障碍的机制有助于理解患者的精神病理并有助于发展新的干预措施以改善患者的社会功能。源于博弈论的游戏范式为患有精神疾病人群的社会互动研究提供了新的途径。尽管目前采用博弈论的游戏范式已经发现精神分裂症患者表现出异常的社会互动行为,但是导致其社会互动功能损伤的心理机制仍不清楚。本研究旨在检验精神分裂症患者的心理理论障碍或神经认知功能损伤是否会中介其异常的社会互动表现。本研究纳入了35名精神分裂症患者与38名健康对照,采用经典最后通牒游戏及其变式-迷你最后通牒游戏,测量了参与者作为回应者面对不同分配方案的拒绝率,并测量了参与者的心理理论能力与神经认知功能。我们发现,在这两种最后通牒游戏中,精神分裂症患者对不公平或对己不利的分配方案的拒绝率都显著低于健康对照,而在迷你最后通牒游戏中,患者对有利于己的分配方案拒绝率高于健康对照。患者的心理理论障碍及神经认知功能损伤也在本研究中得到重复验证。中介分析显示,心理理论损伤可以部分中介两组参与者在迷你最后通牒游戏中的组间差异,而神经认知损伤未发现类似的中介效应。神经认知损伤对两组参与者在心理理论任务中的表现起中介作用。本研究结果揭示了精神分裂症患者的社会互动异常至少部分地与其心理理论障碍有关,而与神经认知功能损伤无直接关系。这一结果加深了对精神分裂症社会互动异常心理机制的理解,且对发展旨在改善患者社会功能的治疗措施具有一定启示作用。更多还原

【Abstract】 Background: Schizophrenia patients often suffer difficulties in social interactions. Using paradigms from game theory, a new way to investigate social interaction in psychiatric populations, abnormal social interaction behaviors have been repeatedly found in schizophrenia patients. However, the psychological mechanisms underlying the social interaction impairments remain unclear. This study aimed to test whether the social interaction impairments in schizophrenia are mediated by theory of mind(To M) deficits or/and neurocognition deficits, both of which are consistently reported in schizophrenia. Methods: 35 schizophrenia patients and 38 healthy controls as responders performed two versions of Ultimatum Game(UG), the classic UG and its variation–mini UG, to detect social interaction behaviors. Neurocognition and To M were also assessed for each participant. Mediation analyses were further performed.Results: Compared with the healthy controls, the schizophrenia patients showed lower rejection rates to the unfair or disadvantageous proposals in both of the two UG tasks, but showed higher rejection rates to the advantageous proposals in the mini UG. Impaired neurocognition and To M were also found in these patients with schizophrenia. Mediation analyses indicated that To M but not neurocognition partially mediated the group differences in the mini UG. Furthermore, neurocognition mediated the group differences in the ToM tasks. Conclusions: Our results revealed that social interaction impairments in patients with schizophrenia may be partly due to their impaired To M, but not directly due to their neurocognition deficits. These findings could improve our understanding on social interaction impairments in schizophrenia and guide further therapies for improving social outcomes of schizophrenia.更多还原