Antimicrobial Berberine Benzimidazoles:Novel DNA Targeting Supramolecular Interaction

【作者】 Ponmani Jeyakkumar； 张玲； Srinivasa Rao Avula； 周成合；

【Author】 Ponmani Jeyakkumar;Ling Zhang;Srinivasa Rao Avula;Cheng-He Zhou;School of Chemistry and Chemical Engineering, Southwest University;CSIR-Central Drug Research Institute;

【机构】 School of Chemistry and Chemical Engineering, Southwest University； CSIR-Central Drug Research Institute；

【摘要】 <正>A novel series of DNA targeting antibacterial berberine-benzimidazoles were developed.Compound 5d was found to exhibit good bioactivity against antibacterial and antifungal strains in comparison with Norfloxacin and Fluconazole.Bacterial membrane permeabilization,Gel electrophoresis and Molecular modelling suggested the possible antibacterial mechanism against更多还原