【作者】 梁浩；

【Author】 Hao Liang;State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology;

【机构】 北京化工大学化工资源有效利用国家级重点实验室；

【摘要】 金属-有机杂化纳米酶催化剂是一类新型原位自组装纳米酶催化体系,具有高的孔隙率和比表面积,结构丰富可调,无需化学修饰改性,合成工艺简单等优点^[1-3]。核苷酸是生命体所含重要有机分子,具有良好生物相容性、多金属结合位点、两亲性和手性。课题组以过渡金属离子为导向基元,以核苷酸分子为有机结构配体,较系统地研究了过渡金属离子-核苷酸杂化酶蛋白自组装反应,通过核苷酸结构单元筛选和合成条件调控,能够合成形貌和结构不同的金属-核苷酸杂化纳米酶催化材料。课题组以氯过氧化物酶（CPO）和假丝酵母脂肪酶（CRL）为客体蛋白分子,成功构建了多种核苷酸基金属杂化纳米结构酶催化剂体系,结果表明酶的稳定性和有机溶剂耐受性也得到显著改善,并且成功应用于左旋莫达菲尼和苯乙醇酸的手性合成。更多还原

【Abstract】 Metal-organic hybrid nano-structured enzymes are a novel in situ self-assemble nano-structured catalysts. We firstly studied the coordination self-assembly of transition metal ions and nucleotides, and different morphology and structure of metal-nucleotide hybrid nanomaterials could be obtained by selecting various nucleotides and controlling the reaction condition. Then, we found that the self-assembly system of metal ions and nucleotides could efficiently encapsulated a variety of enzymes. So we successfully constructed metal-nucleotides hybrid nano-structured enzymes and evaluated their application in the synthesis of chiral compounds.更多还原