【作者】 王杰； 朱君； 何丹农；

【Author】 Jie Wang;Jun Zhu;Dannong He;School of Materials Science and Engineering, Shanghai Jiao Tong University;National Engineering Research Center for Nanotechnology;

【机构】 上海交通大学； 纳米技术及应用国家工程研究中心；

【摘要】 活性氧（ROS）治疗肿瘤的研究已受到广泛的关注,许多方法已被应用产生ROS,从而达到治疗肿瘤的目的^[1-2]。其中,在缺氧条件下,线粒体会产生大量的活性氧,随即大量的活性氧将会诱导机体产生缺氧应激反应。另一方面,光热治疗可以使肿瘤细胞内ROS增加而使癌细胞凋亡。因此,我们选择单壁碳纳米管作为光热治疗的诱发材料,同时结合缺氧环境导致的缺氧应激反应,达到对癌细胞杀伤的三重功效。实验结果表明,这种联合治疗在细胞和动物水平上都具有很好的光热治疗和化疗治疗效果,并且由于缺氧环境的作用,可以在较低的功率和剂量下实现很好的联合治疗效果,有可能在纳米生物医学中得到进一步的应用。更多还原

【Abstract】 Reactive oxygen species(ROS) on cancer treatment has been widely concerned and many methods have been applied to produce ROS in order to treat tumor. Under the condition of hypoxia, mitochondria will generate a large amount of ROS, which will induce the body to produce hypoxia stress reaction. On the other hand, photothermal therapy can increase the ROS in tumor cells and cause apoptosis of cancer cells. So we choose single-walled carbon nanotubes which can increase intracellular ROS in itself, combined with hypoxia environment can lead to hypoxia stress reaction to reach triple effect on cancer cell killing. Experimental results show that this combination therapy has good treatment effect on cellular and animal level, and because of the role of hypoxia environment, it can achieve good effect of the combination therapy in lower power and dosage, which may obtain further applications in nano biomedicine.更多还原