【作者】 王丽萍； 李娟； 吴淑贤； 杨黄浩；

【Author】 Juan Li;Shu-Xian Wu;Cui-Chen Wu;Li-Ping Qiu;Huang-Hao Yang;College of Chemistry, Fuzhou University;

【机构】 福州大学食品安全分析与检测技术教育部重点实验室化学学院；

【摘要】 如何实现抗肿瘤药的靶向给药和可控释放,是药物释放研究领域的焦点问题。本工作通过原位聚合的方法,制备了以生物可降解的聚多酚为包裹壳层的介孔硅纳米颗粒（MSNs）,用于构建靶向可控的药物递送体系。该药物递送体系以高负载能力的MSN作为药物载体,选用自然多酚充当多功能封孔材料。聚多酚壳层不仅能防止负载药物在给药过程中的提前泄露,还能够为靶向分子（核酸适配体）提供固定平台,并且能够在细胞内的酸性环境中以及谷胱甘肽（GSH）的作用下会发生生物降解,从而实现MSNs中负载的抗癌药物的释放^[1]。因此,这种生物相容性良好的MSN药物递送体系能够实现靶向抗癌药物输送和可控药物释放,在癌症治疗方面具有良好的应用前景。更多还原

【Abstract】 Designing smart drug delivery systems with targeted recognition and controlled release is the critical issue for researchers. Herein, we synthesized biodegradable polyphenol-coated porous nanomaterials(MSNs) for targeted and controlled drug delivery. MSNs acted as a drug carrier with high loading capability, while the polyphenol acted as multifunctional gate keeper. The polyphenol coatings not only prevented premature drug leakage, but also provided a scaffold for the immobilization of targeting moieties, such as aptamers. Besides, the polyphenol coating could be biodegraded by acidic p H and intracellular glutathione, resulting in the release of trapped anticancer drugs. As a result, these biocompatible MSNs based drug delivery systems enable for targeted drug delivery and controllable drug release, which are promising for cancer therapy.更多还原