【作者】 吴娜； 宗嘉骏； 李涛； 俞亚东； 黄和； 汤瀚林； 朱沙阳子； 曹群；

【Author】 Na Wu;Jiajun Zong;Tao Li;Yadong Yu;He Huang;Hanling Tang;Shayangzi Zhu;Qun Cao;College of Biotechnology and Pharmaceutical Engineering,Nanjing Tech University;Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM);School of Pharmaceutical Sciences,Nanjing Tech University;

【机构】 南京工业大学生物与制药工程学院； 国家"江苏先进生物与化学制造协同创新中心"； 南京工业大学药学院；

【摘要】 近年来的研究发现二硫化钼(Mo S2)是一种具有许多独特性质的二维层状材料,在医药、能源、传感等众多领域的研究和应用日益增多。然而关于Mo S2对环境微生物的影响研究尚不多见。本研究采用代谢组学等方法考察了不同浓度二硫化钼纳米片对大肠杆菌的影响,结果显示随着二硫化钼纳米片浓度的增加,大肠杆菌的存活率显著降低,同时乳酸脱氢酶(LDH)释放量和活性氧(ROS)含量逐渐增加,此外高浓度二硫化钼纳米片显著影响大肠杆菌的正常代谢。更多还原

【Abstract】 Molybdenum disulfide(Mo S2),a type of two-dimensional layered materials with many unique properties,has been applied in many fields such as medicine,energy,and sensor.However,the effects of Mo S2 on environmental microbial is still unclear.In this study,we utilized the methods including metabolomics technology to explore the effects of different concentrations of Mo S2 on Escherichia coli(E.coli).The results showed that with the increasing concentration of Mo S2,the survival rate of E.coli was significantly decreased.Meanwhile,the release of lactic dehydrogenase(LDH)and reactive oxygen species(ROS) were dramatically increased.In addition,the high concentration of Mo S2 could significantly affect the metabolism of E.coli.更多还原