【作者】 吕永博； 周颖； 李德富； 穆畅道；

【Author】 LV Yong-bo;ZHOU Ying;LI De-fu;MU Chang-dao;College of Chemical Engineering,Sichuan University;

【机构】 四川大学化学工程学院；

【摘要】 纯胶原敷料容易受到细菌侵蚀,限制了其应用,因此需对其进行改性。本文采用不同氧化程度的氧化直链淀粉包合芳樟醇制备成包合物。将胶原和包合物共混,冷冻干燥制成复合胶原敷料,并对其结构与性能进行表征。结果表明,随着氧化直链淀粉氧化程度及添加量的增加,复合胶原敷料的孔隙逐渐减小,且低氧化程度直链淀粉和胶原纤维会发生局部的微相分离。包合物的添加使复合胶原敷料获得优异的抗菌性能且能大幅度降低外界细菌的侵蚀。复合敷料具有较高的吸水能力及适宜的水蒸气透过率。血液相容性测试表明复合胶原敷料的血液相容性得到了提升。更多还原

【Abstract】 Collagen dressings have a poor antibacterial property,which limits its application.Therefore,collagen dressings need to be modified.In this study,amylose was oxidized to prepare oxidized amylose with different degrees,which was used as the host molecule to encapsulate an antibacterial molecule-linalool.The inclusion complex was then mixed with collagen to prepare composite dressing.These results showed that the introduction of inclusion complexes decreased the pore size of collagen dressing and low degree of oxidized amylose could lead to microphase separation.It was observed that the composite dressing showed excellent broad-spectrum antibacterial effect and could prevent outside bacterial invasion.Moreover,the composite dressings had adaptive water absorbing capacity and WVTR.The in vitro blood compatibility test indicated that the hemocompatibility of composite dressing had been enhanced.更多还原