【作者】 刘旭东； 李建军； 王盛章； 张晓龙；

【Author】 LIU Xu-dong;MENG Zhuang-yuan;WANG Sheng-zhang;ZHANG Xiao-long;institute of Biomechanics,Department of Aeronautics and Astronautics,Fudan University;Department of Radiology,Huashan Hospital affiliated to Fudan University;

【机构】 复旦大学航空航天系生物力学研究所； 复旦大学附属华山医院放射科；

【摘要】 本文选取具有上下分布的双瘤囊的脑动脉瘤模型,且其中一个瘤囊上带有一个小的侧枝血管;利用快速虚拟释放的方法将两种具有不同金属覆盖率的血流导向支架LVIS和Pipeline植入这例脑动脉瘤中;利用计算流体动力学的方法模拟血流导向支架植入前后的脑动脉瘤模型中的血液流动;分析血流速度、壁面切应力以及侧枝血管的血流量的变化。结果发现植入Pipeline之后瘤囊内的血流速度和瘤壁上的壁面切应力相对于LVIS支架植入显著下降,且植入Pipeline后侧枝血流量也大于植入LVIS的。因此,Pipeline比LVIS在栓塞动脉瘤方面有更好的效果,但同时Pipeline植入后动脉瘤破裂的风险比LVIS更大,而植入血流导向支架后侧枝血管的血流量并不会显著减小。更多还原

【Abstract】 In this article,a pair of intracranial aneurysms,both located at the two sides of the parent artery and one aneurysm sac had a branch vessel,were treated virtually with two kinds of flow diverting stents:LVIS and Pipeline by rapid deployment method.The blood flows in the pair of aneurysms before and after treatment were simulated by computational fluid dynamics and the hemodynamic parameters such as velocity,wall shear stress were calculated.Analyzing the numerical results,it was observed that velocity reduction of the treated aneurysms with Pipeline was much larger than with LVIS,wall shear stress on the treated aneurysm with Pipeline is much smaller than with LVIS,and the increment of flow rate at the branch vessel after the aneurysm treated with Pipeline was larger than that with LVIS.The following conclusions can be summarized that Pipeline is more effective to occlude the aneurysm than LVIS,but the aneurysm treated with Pipeline has more rupture risk than with LVIS.The branch vessel located at the aneurysm sac has suction effect when the aneurysm is treated with flow diverting stent,which reduces velocity further inside the aneurysm sac and benefits embolization formation.更多还原